Protein Alignment Shaw and Kcnc3

DIOPT Version :10

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_446449.2
• Gene: Kcnc3 / 117101
• RGDID: 621358
• Length: 769
• Species: Rattus norvegicus
• Alignment Length: 612
• Identity: 258/612 - (42%)
• Similarity: 336/612 - (54%)
• Gaps: 104/612 - (16%)

  Fly    26 RVVLNVGGIRHETYKATLKKIPATRLSRLTE----ALANYDPILNEYFFDRHPGVFAQVLNYYRT 86
            ::|:||||:|||||::||:.:|.|||:.|||    |..:|||..:|:||||||||||.|||||||
  Rat    91 KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGTDEFFFDRHPGVFAYVLNYYRT 155

  Fly    87 GKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELA 151
            ||||.|.|||||||||||.|||:|...||.||||||.||||.:|.|...:..|......:....|
  Rat   156 GKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDSSGNANANAGGA 220

  Fly   152 RKFGFEE---------DYYKGTI------------------------SWWQEMKPRIWSLFDEPY 183
            ...|.::         |...|.:                        :||:..:||:|:||::||
  Rat   221 HDAGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPAGGPGGAGGTWWRRWQPRVWALFEDPY 285

  Fly   184 SSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPIVRNITVKTAN---GSNGWFLDKTQTNAHIA 245
            ||.||:.:...|:|||.|||.:|||:||...  ..:.|.||..|:   |:....:...:......
  Rat   286 SSRAARYVAFASLFFILISITTFCLETHEGF--IHISNKTVTQASPIPGAPPENITNVEVETEPF 348

  Fly   246 FFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILE 310
            ..|:|.||..|||||.|:|....|:|.||:|||:||||.:|.|.||:::.|...:|.... |:|.
  Rat   349 LTYVEGVCVVWFTFEFLMRVTFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAK-DVLG 412

  Fly   311 FFSI---IRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNP 372
            |..:   :||:|:||||||..||::|..|.|||..|..||:.||.||::|||:::||||||..:|
  Rat   413 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADP 477

  Fly   373 -------HNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSN 430
                   |..|.:||:|.|||:|||||:|||||.|||:.||.||||||||||||||:||||||:|
  Rat   478 DDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNN 542

  Fly   431 FAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAPGGVSGCGTPGSGPHSGPMGSGGTGPRRMN 495
            |.||||...|:.|||||:.:.:|     :|..||:|........|...||. ..||||..|
  Rat   543 FGMYYSLAMAKQKLPKKKNKHIP-----RPPQPGSPNYCKPDPPPPPPPHP-HHGSGGISP---- 597

  Fly   496 NKTKDLVSPKSVAQLFAGPLGASIVAMSPRTMLDLNPALAMGKPTFQPRIPTPLAATPPPPVSSA 560
               ...::|.|:....||                                     |.||.| .:.
  Rat   598 ---PPPITPPSMGVTVAG-------------------------------------AYPPGP-HTH 621

  Fly   561 GGMTASGIGTTSATGATSAPQPATPLP 587
            .|:...|.|.....|....|.|..|.|
  Rat   622 PGLLRGGAGGLGIMGLPPLPAPGEPCP 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB_Shaw-like	24..135	CDD:349723	75/112 (67%)
		Ion_trans	188..439	CDD:459842	131/263 (50%)
		PRK14959	<418..>585	CDD:184923	49/166 (30%)
Kcnc3	NP_446449.2	BTB_KCNC1_3	91..204	CDD:349721	75/112 (67%)
		Ion_trans	290..551	CDD:459842	131/263 (50%)