DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and Kcns1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_446406.1	Gene:	Kcns1 / 117023	RGDID:	621524	Length:	497	Species:	Rattus norvegicus

Alignment Length:	442	Identity:	136/442 - (30%)
Similarity:	222/442 - (50%)	Gaps:	54/442 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LNVGGIRHETYKATLKKIPATRLSRLTEALA---------NYDPILNEYFFDRHPGVFAQVLNYY 84
            :||||:|.......|.:.|.|||.||..|::         :||....|::||||||.|..:|::|
  Rat    23 VNVGGVRRLLSARALARFPGTRLGRLQAAVSEEQARRLCDDYDAAAREFYFDRHPGFFLGLLHFY 87

  Fly    85 RTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPS--- 146
            |||.||...::|...|.:|.::|||..|.:..||...|.:.|.|:..     ..|.|::.||
  Rat    88 RTGHLHVLDELCVFAFGQEADYWGLGENALATCCRARYLERRVTRPR-----AWDEDSDAPSSVD 147

  Fly   147 ---------EEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICIS 202
                     :.|||| :|         .:....::.|:|...:.|..|..:|....||:..:..|
  Rat   148 PCPDEISDVQRELAR-YG---------AARCGRLRRRLWLTMENPGYSLPSKLFSCVSIGVVLAS 202

  Fly   203 ILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFIS 267
            |.:.|:.:.|:.:...........|.|.:...:........:.:|     |.|||:||:..|.:.
  Rat   203 IAAMCIHSLPEYQAREAAAAVAAVAAGRSAEDVRDDPVLRRLEYF-----CIAWFSFEVSSRLLL 262

  Fly   268 SPNKWEFIKSSVNIIDYIATLSFYIDLVL------QRFASHLENAD---ILEFFSIIRIMRLFKL 323
            :|:...|....:|:||.::.|.||:.|:.      :|.||..|..|   :::.|.::||.|:.||
  Rat   263 APSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALGDRRGASGEELGDLGKVVQVFRLMRIFRVLKL 327

  Fly   324 TRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALV 388
            .|||:||:.|..|.:.|.:|:.:|:.:|.:|:.:|:.:.|.||    ..:..|::||...||..|
  Rat   328 ARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAE----EKNVGFDTIPACWWWGTV 388

  Fly   389 TMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQA 440
            :||||||||:.|:|..|....:.|.|.|:|.:|||:.:|.:.|:.:|...:|
  Rat   389 SMTTVGYGDVVPETVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKA 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	40/104 (38%)
		BTB_2	27..117	CDD:280393	37/96 (39%)
		Ion_trans	244..439	CDD:278921	71/203 (35%)
		Ion_trans_2	355..429	CDD:285168	29/73 (40%)
Kcns1	NP_446406.1	BTB_2	21..120	CDD:280393	37/96 (39%)
		BTB	23..125	CDD:197585	39/101 (39%)
		Ion_trans	238..439	CDD:278921	71/209 (34%)
		Ion_trans_2	355..433	CDD:285168	32/81 (40%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	392..397		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820