Protein Alignment Shaw and Kcnd1

DIOPT Version :9

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001099218.1
• Gene: Kcnd1 / 116695
• RGDID: 621364
• Length: 650
• Species: Rattus norvegicus
• Alignment Length: 666
• Identity: 214/666 - (32%)
• Similarity: 306/666 - (45%)
• Gaps: 157/666 - (23%)

  Fly    27 VVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHY 91
            :|:||.|.|.||:|.||.:.|.|.|.. :|....||....||||||.|.:|..|||:||||:||.
  Rat    42 LVVNVSGRRFETWKNTLDRYPDTLLGS-SEKEFFYDAESGEYFFDRDPDMFRHVLNFYRTGRLHC 105

  Fly    92 PTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELARKFGF 156
            |...|...|:|||.|:||....|..||...|.            ||...:.|:.:|:|.|.:.|.
  Rat   106 PRQECIQAFDEELAFYGLVPELVGDCCLEEYR------------DRKKENAERLAEDEEAEQAGE 158

  Fly   157 EEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPIVRN 221
            ......|:     .::.|:|..|:.|::|.||.....|:.|||.:|:::..::|.| .|.| .|.
  Rat   159 GPALPAGS-----SLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIP-CRGP-ARW 216

  Fly   222 ITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIA 286
            .|.:...|      |:..|    |||.::..|...||.|.|:|..::|::..|::|.:::||.:|
  Rat   217 PTKEQPCG------DRFPT----AFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVA 271

  Fly   287 TLSFYIDLVLQRFASHLENADILEFF---SIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLV 348
            .|.:||.|.:.:      |.|:...|   .:.|:.|:||.:|||.||:||..|.::.|.||..|:
  Rat   272 ILPYYIGLFVPK------NDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLL 330

  Fly   349 FFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCA 413
            |.|.:.|:|||::::|||:  .....:|.|||...|:.:|||||:|||||.|.|..|...|::|:
  Rat   331 FSLTMAIIIFATVMFYAEK--GTSKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICS 393

  Fly   414 LAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAPGGVS-------- 470
            |:|||.||||||||||||:..| |...||...:.:::|      |..|:..|..|.:
  Rat   394 LSGVLVIALPVPVIVSNFSRIY-HQNQRADKRRAQQKV------RLARIRLAKSGTTNAFLQYKQ 451

  Fly   471 --GCGTPGSGP------------------------------------------------------ 479
              |....|||.
  Rat   452 NGGLEDSGSGEGQMLCVRSRSAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSLGGRTSRST 516

  Fly   480 --HSGPMGSGG--------TGPR---RMNNKTKDLVSPKSVAQL--FAG------PLGASIVAMS 523
              .|.|||.|.        .|.|   |:.|.|.. ||..|:.:|  .||      |...|.:...
  Rat   517 SVSSQPMGPGSLFSSCCSRRGERRAIRLANSTAS-VSRGSMQELDTLAGLRRSPAPQSRSSLNAK 580

  Fly   524 PRTMLDLN-------PALAMGKPTFQPRIPTPLAATP-PPPVSSAGGMTASGIGTTSATGATSAP 580
            |...||||       .|:.        .||||.|.|| ....||.||..:.|:..|:...::.
  Rat   581 PHDSLDLNCESRDFVAAII--------SIPTPPANTPDESQPSSPGGGGSGGMANTTLRNSSL-- 635

  Fly   581 QPATP--LP-SIAVST 593
              |||  || ::.:|:
  Rat   636 --ATPCLLPETVKISS 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	46/97 (47%)
		BTB_2	27..117	CDD:280393	43/89 (48%)
		Ion_trans	244..439	CDD:278921	85/197 (43%)
		Ion_trans_2	355..429	CDD:285168	39/73 (53%)
Kcnd1	NP_001099218.1	BTB_POZ	6..143	CDD:365784	48/113 (42%)
		Ion_trans	185..417	CDD:395416	99/252 (39%)
		DUF3399	447..550	CDD:403174	14/102 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810