DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcnk3

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_031757747.1	Gene:	kcnk3 / 116410805	XenbaseID:	XB-GENE-956081	Length:	378	Species:	Xenopus tropicalis

Alignment Length:	371	Identity:	73/371 - (19%)
Similarity:	125/371 - (33%)	Gaps:	118/371 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 AVLDRLDLDTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFD-EPYSSNAAKTIGVVSV 196
            ||.|.|:.:.|...:::|.:|.|.....|..|...:||::   |.:.. :|:.:....|.  ...
Frog    24 AVFDALESEKETTEKQDLEKKRGELWSKYNLTEEKYQELE---WVVLKLKPHKAGVQWTF--AGS 83

  Fly   197 FFICISILS----------------FCLKTHPDMRVPI--------------------------- 218
            |:..|::::                ||: .:..:.:|:
Frog    84 FYFAITVITTIGYGHAAPSTDGGKVFCM-FYALLGIPLTLVMFQSLGERINTLVRYLLHRMKKCL 147

  Fly   219 -VRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNII 282
             :|...|..||            ...|.||  .|:.    |..|.....||..:|.|..:.....
Frog   148 GMRRAEVSMAN------------MVTIGFF--SCIS----TLCIGAAAFSSYEQWSFFHAYYYCF 194

  Fly   283 DYIATLSFYIDLVLQRFASHLENADILEFFSIIRIMRLFKLTRHSSGLKILIQTF--------RA 339
            ..:.|:.|...:.||:.|: |:.......||.:.|  |..||...:.|.:::..|        :.
Frog   195 ITLTTIGFGDYVALQKDAA-LQTKPQYVAFSFVYI--LIGLTVIGAFLNLVVLRFMTMNAEDEKR 256

  Fly   340 SAKELTLL----------------------VFFLVLGIVIFASLVYY--AERIQPNPHNDFNSIP 380
            .|:...||                      |:..||......|.::|  .|::|       .|||
Frog   257 DAEHRALLTRNGHSSIHTTDTSSSSGGFRNVYAEVLHFQSMCSCLWYKSREKLQ-------YSIP 314

  Fly   381 LGLWWALVTM-TTVGYGDMAPKTYIGM-FVGALC-----ALAGVLT 419
            :.:...|.|. |.|..|::.|...|.. ..|.:|     |::.|.|
Frog   315 MIIPRDLSTSDTCVEQGNLTPGRCISTPSNGCICNNQHSAISSVST 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585
		BTB_2	27..117	CDD:280393
		Ion_trans	244..439	CDD:278921	49/215 (23%)
		Ion_trans_2	355..429	CDD:285168	19/74 (26%)
kcnk3	XP_031757747.1	Ion_trans_2	<77..132	CDD:400301	6/57 (11%)
kcnk3	XP_031757747.1	Ion_trans_2	167..247	CDD:400301	20/86 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000