Protein Alignment Shaw and kcnd2

DIOPT Version :10

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: XP_012815411.2
• Gene: kcnd2 / 105946842
• XenbaseID: XB-GENE-952449
• Length: 627
• Species: Xenopus tropicalis
• Alignment Length: 485
• Identity: 163/485 - (33%)
• Similarity: 256/485 - (52%)
• Gaps: 70/485 - (14%)

  Fly    24 ENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGK 88
            ::.:||||.|.|.:|::.||::.|.|.|.. ||....::....||||||.|.:|..:||:||||:
 Frog    40 DSLIVLNVSGTRFQTWRNTLERYPDTLLGS-TERDFFFNQDSGEYFFDRDPDIFRHILNFYRTGR 103

  Fly    89 LHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTY-TQHRDTQETLAVLDRLDLD-TEKPSEEELA 151
            ||||...|...::|||.|:|:....:..||:..| .:.|:..|.|  ||..|.: .|.|.....|
 Frog   104 LHYPRHECISAYDEELAFFGIIPEIIGDCCYEEYKDRRRENAERL--LDDADENKAEGPLPPMSA 166

  Fly   152 RKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHP---- 212
            |:                    ::|..|:.|::|..|.....|:.|||.:|:::..::|.|
 Frog   167 RQ--------------------KMWRAFENPHTSTLALVFYYVTGFFIAVSVIANVVETVPCGIS 211

  Fly   213 --DMR-VPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEF 274
              .:| :|......                    :|||.::..|...||.|.|:|.:::|:::.|
 Frog   212 PGSLRELPCGERYA--------------------LAFFCLDTACVMIFTVEYLLRLVAAPSRYRF 256

  Fly   275 IKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFF---SIIRIMRLFKLTRHSSGLKILIQT 336
            ::|.::|||.:|.:.:||.||:      ..|.|:...|   .:.|:.|:||.:|||.||:||..|
 Frog   257 VRSVMSIIDVVAIMPYYIGLVM------TNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYT 315

  Fly   337 FRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPK 401
            .::.|.||..|:|.|.:.|:|||::::|||:...|  :.|.|||...|:.:|||||:|||||.||
 Frog   316 LKSCASELGFLLFSLTMAIIIFATVMFYAEKGSLN--SRFTSIPAAFWYTIVTMTTLGYGDMVPK 378

  Fly   402 TYIGMFVGALCALAGVLTIALPVPVIVSNFA-MYYSHTQARAKLPKKRRRVLPVEQPR----QPR 461
            |..|...|::|:|:|||.||||||||||||: :|:.:.:|..:..:|:.|:..:...:    ...
 Frog   379 TIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKTRLARIRLAKSGSANAY 443

  Fly   462 LPGAPGGVSGCGTPGSGPHSGPM--GSGGT 489
            |.....|:......||.....|:  .||.|
 Frog   444 LQSKRNGLLNEALQGSSEEEQPLVSKSGST 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB_Shaw-like	24..135	CDD:349723	44/111 (40%)
		Ion_trans	188..439	CDD:459842	97/261 (37%)
		PRK14959	<418..>585	CDD:184923	25/79 (32%)
kcnd2	XP_012815411.2	BTB_POZ	6..144	CDD:453885	42/104 (40%)
		Ion_trans	183..414	CDD:459842	97/258 (38%)
		DUF3399	470..542	CDD:463381	3/4 (75%)