DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and kcnd2

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_012815411.2	Gene:	kcnd2 / 105946842	XenbaseID:	XB-GENE-952449	Length:	627	Species:	Xenopus tropicalis

Alignment Length:	480	Identity:	165/480 - (34%)
Similarity:	257/480 - (53%)	Gaps:	60/480 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGK 88
            ::.:||||.|.|.:|::.||::.|.|.|.. ||....::....||||||.|.:|..:||:||||:
Frog    40 DSLIVLNVSGTRFQTWRNTLERYPDTLLGS-TERDFFFNQDSGEYFFDRDPDIFRHILNFYRTGR 103

  Fly    89 LHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTY-TQHRDTQETLAVLDRLDLD-TEKPSEEELA 151
            ||||...|...::|||.|:|:....:..||:..| .:.|:..|.|  ||..|.: .|.|.....|
Frog   104 LHYPRHECISAYDEELAFFGIIPEIIGDCCYEEYKDRRRENAERL--LDDADENKAEGPLPPMSA 166

  Fly   152 RKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRV 216
            |:                    ::|..|:.|::|..|.....|:.|||.:|:::..::|.|....
Frog   167 RQ--------------------KMWRAFENPHTSTLALVFYYVTGFFIAVSVIANVVETVPCGIS 211

  Fly   217 PIVRNITVKTANGSNGWFLDKTQTNAH--IAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSV 279
            |           ||    |.:......  :|||.::..|...||.|.|:|.:::|:::.|::|.:
Frog   212 P-----------GS----LRELPCGERYALAFFCLDTACVMIFTVEYLLRLVAAPSRYRFVRSVM 261

  Fly   280 NIIDYIATLSFYIDLVLQRFASHLENADILEFF---SIIRIMRLFKLTRHSSGLKILIQTFRASA 341
            :|||.:|.:.:||.||:      ..|.|:...|   .:.|:.|:||.:|||.||:||..|.::.|
Frog   262 SIIDVVAIMPYYIGLVM------TNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCA 320

  Fly   342 KELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGM 406
            .||..|:|.|.:.|:|||::::|||:...|  :.|.|||...|:.:|||||:|||||.|||..|.
Frog   321 SELGFLLFSLTMAIIIFATVMFYAEKGSLN--SRFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGK 383

  Fly   407 FVGALCALAGVLTIALPVPVIVSNFA-MYYSHTQARAKLPKKRRRVLPVEQPR----QPRLPGAP 466
            ..|::|:|:|||.||||||||||||: :|:.:.:|..:..:|:.|:..:...:    ...|....
Frog   384 IFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKTRLARIRLAKSGSANAYLQSKR 448

  Fly   467 GGVSGCGTPGSGPHSGPM--GSGGT 489
            .|:......||.....|:  .||.|
Frog   449 NGLLNEALQGSSEEEQPLVSKSGST 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	41/98 (42%)
		BTB_2	27..117	CDD:280393	38/89 (43%)
		Ion_trans	244..439	CDD:278921	87/198 (44%)
		Ion_trans_2	355..429	CDD:285168	41/73 (56%)
kcnd2	XP_012815411.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910