DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcnk4a

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_021336981.1	Gene:	kcnk4a / 101885817	ZFINID:	ZDB-GENE-141211-80	Length:	485	Species:	Danio rerio

Alignment Length:	318	Identity:	61/318 - (19%)
Similarity:	100/318 - (31%)	Gaps:	131/318 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 RASAKELTLL---------------VFFLVLGIVIFASLVYYAERIQPNPHNDFN-----SIPLG 382
            ||.||..||.               ||.:::|.::|.::          |...|.     |:...
Zfish    88 RAVAKVETLFLRKGVKPTSVRIISAVFSILIGCLVFIAV----------PTMVFQEVESWSLLEA 142

  Fly   383 LWWALVTMTTVGYGDMA------------PKTYIGMFVGALCALAGVLTI--------------- 420
            :::.::|:||||:||..            |..::.:..| |...|.:||:
Zfish   143 VYFVVITLTTVGFGDYVAENRRDGTPLYKPLVWLWIVFG-LAYFASILTMIGNWLRVLSKKTRAE 206

  Fly   421 ----------------------ALPVPVIVSNFAMYYSHTQARAKLPKKRRRVL------PVEQP 457
                                  .:|||:.:::          ..:|.::|||..      ....|
Zfish   207 MEELRAHATDWTQNIQNMSMDFRIPVPLDLND----------PFQLQRRRRRKRHHHHHHHHRHP 261

  Fly   458 RQPRLPGAPGGVS--------------GCGTPGSGPHSGPMGSGGTGPRRMNNKTKDLVSPKSVA 508
            | |...|...|:|              |..|....|.|..:...    |.|:.........:..:
Zfish   262 R-PNTTGLTHGISLDADIIRENGHLILGWPTCRYKPASEVLSQS----RSMSRIDGAHYEMRPGS 321

  Fly   509 QLFAGPLGASIVAMSPRTMLDLNPALAMGKPTFQPRIPTPLAATPPPPVSSAGGMTAS 566
            :|..||...||      :.|:|.||...|.          .|.:..|..|.:|..:||
Zfish   322 RLTVGPTSRSI------SRLELKPASRAGS----------RAISRSPSQSESGSFSAS 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585
		BTB_2	27..117	CDD:280393
		Ion_trans	244..439	CDD:278921	29/169 (17%)
		Ion_trans_2	355..429	CDD:285168	20/127 (16%)
kcnk4a	XP_021336981.1	Ion_trans_2	24..80	CDD:311712
		Ion_trans_2	116..197	CDD:311712	18/91 (20%)
		THRAP3_BCLAF1	329..>419	CDD:317794	13/51 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000