DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and LOC100536252

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_003201808.1	Gene:	LOC100536252 / 100536252	-ID:	-	Length:	476	Species:	Danio rerio

Alignment Length:	486	Identity:	180/486 - (37%)
Similarity:	258/486 - (53%)	Gaps:	86/486 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTYIPKKM--QHYAHAAMNLINMDSE-------NRVVLNVGGIRHETYKATLKKIPATRLSRLTE 56
            ||.:|.:.  :..|.||::....|.|       .|||:|:.|:|.||...||.:.|||.|....:
Zfish     1 MTVVPGENLDETVALAALSQDAYDPERADQECCERVVINISGLRFETQLKTLAQFPATLLGDPRK 65

  Fly    57 ALANYDPILNEYFFDRHPGVFAQVLNYYRT-GKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWM 120
            .:..:||:.|||||||:...|..:|.||:: |:|..|.:|...:|.||::|:.|.
Zfish    66 RMRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPVDIFMEEIKFYELG---------- 120

  Fly   121 TYTQHRDTQETLAVLDRLDLDTEKPSEEELARKFGFEEDYYKGTISWWQEMKP--------RIWS 177
                                       ||:...|..:|.:.|      :|.:|        ::|.
Zfish   121 ---------------------------EEVIENFKEDEGFIK------EEERPLPESEFQRQVWL 152

  Fly   178 LFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNA 242
            ||:.|.||..|:.|.:|||..|.|||:.|||  .|:.|..   ....:...|.||......:.|.
Zfish   153 LFEYPESSGPARGIAIVSVLVILISIVIFCLXXLPEFRED---GKAFEEHPGVNGTAASVKKPNP 214

  Fly   243 HI-AFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENA 306
            .. .||.:|.:|..||:||:||||::.|:|..|.|:.:|.||.:|.:.::|.|.|: .|.|..|.
Zfish   215 FTDPFFIVETLCIIWFSFELLVRFLACPSKPAFFKNIMNTIDIVAIIPYFITLGLE-LAEHQGNG 278

  Fly   307 D------ILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYA 365
            .      ||....::|:.|:|||:|||.||:||.:|.:||.:||.||:|||.:|:::|:|.||:|
Zfish   279 QQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFA 343

  Fly   366 ERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSN 430
            |  ..:|.:.|:|||...|||:|:|||||||||.|.|..|..||:|||:||||||||||||||||
Zfish   344 E--TDDPDSGFSSIPDAFWWAVVSMTTVGYGDMCPVTIGGKIVGSLCAIAGVLTIALPVPVIVSN 406

  Fly   431 F------------AMYYSHTQARAKLPKKRR 449
            |            .|.|:|.....::.:.||
Zfish   407 FNYFYHRETEHEEQMQYTHVTCGQQVGEFRR 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	35/98 (36%)
		BTB_2	27..117	CDD:280393	35/90 (39%)
		Ion_trans	244..439	CDD:278921	103/213 (48%)
		Ion_trans_2	355..429	CDD:285168	45/73 (62%)
LOC100536252	XP_003201808.1	BTB	36..125	CDD:197585	37/125 (30%)
		BTB_2	36..125	CDD:280393	37/125 (30%)
		Ion_trans	212..414	CDD:278921	101/204 (50%)
		Ion_trans_2	328..405	CDD:285168	48/78 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910