DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcnv2

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_002934230.1	Gene:	kcnv2 / 100498412	XenbaseID:	XB-GENE-940169	Length:	562	Species:	Xenopus tropicalis

Alignment Length:	511	Identity:	146/511 - (28%)
Similarity:	241/511 - (47%)	Gaps:	97/511 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TYIPKKMQHYAHAAMNLINMDSENRVVLNVGGIRHETYKATLKKIPATRLSRLT---------EA 57
            :|..||.:...|               :||||..:..........|.:|:.||.         :.
Frog   100 SYYGKKRRKSLH---------------INVGGTSYRISYGVAASYPKSRIGRLATYTDRQRKLDL 149

  Fly    58 LANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTY 122
            ..:|.|..:.|||||.|.:|..:.|:||||.|....::|...|.||:.:||:.......||.:::
Frog   150 CDDYSPKEDVYFFDRDPAIFHHIYNFYRTGVLWVRDELCPRSFLEEINYWGVRVKHTPRCCRISF 214

  Fly   123 TQHR-DTQETLAVLDRLDLDTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSN 186
            .:.: |..|.|.|...|..:.|....|||          ::|.:  :..::.|||::.::|:||.
Frog   215 EERQDDLNEQLKVQRELRAEMETEENEEL----------FRGML--YGHLRRRIWNMMEKPFSSV 267

  Fly   187 AAKTIGVVSVFFICISILSFCLKTHPDMRVPIVRNITVKTANG--SNGWFLDKTQTNAHIAFFYI 249
            .||.|.|.|.||:.||:::..|.|..||:        .|.|.|  |...:|:           ::
Frog   268 TAKAIAVASSFFVLISVVAMTLNTVEDMQ--------YKNAAGLPSGKPYLE-----------HV 313

  Fly   250 ECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFA---------SHLEN 305
            |.:|..:||.|.|:|.:|:|:...|.:|.:|.:|.||.|..|:.::|:.||         ||...
Frog   314 ETLCITFFTLEYLLRLMSTPDLQHFGRSVLNAVDLIAILPLYLQMLLESFADEDRSGKGSSHEHE 378

  Fly   306 AD----------ILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFAS 360
            .:          :|....::||.|:.||.|||:||:....|.|...:::..|..|:.:|:..|::
Frog   379 IEAVGRVGKLGQVLRIMRLMRIFRILKLARHSTGLRAFGFTLRQCYQQVGCLFLFIAMGVFSFSA 443

  Fly   361 LVYYAERIQPNPHN----DFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIA 421
            :||..|      |:    :|.|||...|||.|:::||||||:.|:|::|.....||...|::...
Frog   444 MVYSVE------HDVSGTNFTSIPHAWWWAAVSISTVGYGDVYPETHLGRLFAFLCIAFGIILNG 502

  Fly   422 LPVPVIVSNFAMYYSHTQA--RAKLPKKRRRVLPVEQPRQ--------PRLPGAPG 467
            :|:.::.:.|:.|||..::  ...:.|||.:|....:..|        |.:|..||
Frog   503 MPISILYNKFSDYYSKLKSYEYTTIRKKRGKVHFTGRAVQKVNSCCCGPPVPNTPG 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	31/106 (29%)
		BTB_2	27..117	CDD:280393	29/98 (30%)
		Ion_trans	244..439	CDD:278921	68/217 (31%)
		Ion_trans_2	355..429	CDD:285168	26/77 (34%)
kcnv2	XP_002934230.1	BTB	112..212	CDD:197585	31/99 (31%)
		BTB	112..201	CDD:295341	28/88 (32%)
		Ion_trans	310..520	CDD:278921	69/226 (31%)
		Ion_trans_2	445..508	CDD:285168	25/68 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010