DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcnc1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_031756512.1	Gene:	kcnc1 / 100497402	XenbaseID:	XB-GENE-996920	Length:	644	Species:	Xenopus tropicalis

Alignment Length:	300	Identity:	146/300 - (48%)
Similarity:	198/300 - (66%)	Gaps:	21/300 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 IGVVSVFFICISILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNA 255
            :...|:|||.:||.:|||:||......:.:..|....|.:...|..:::|.|.:.  |||.||..
Frog   261 VAFASLFFILVSITTFCLETHETFNPIVNKTETEVVGNETQLRFYRESETEAFLT--YIEGVCVV 323

  Fly   256 WFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFFSI---IRI 317
            |||||.|:|....|||.||||:::||||::|.|.||:::.|...:|.... |:|.|..:   :||
Frog   324 WFTFEFLMRITFCPNKVEFIKNTLNIIDFVAILPFYLEVGLSGLSSKAAK-DVLGFLRVVRFVRI 387

  Fly   318 MRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNP-------HND 375
            :|:||||||..||::|..|.|||..|..||:.||.||::|||:::||||||..||       |..
Frog   388 LRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGANPNDPSASEHTQ 452

  Fly   376 FNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQA 440
            |.:||:|.|||:|||||:|||||.|||:.||.||||||||||||||:||||||:||.||||...|
Frog   453 FKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMA 517

  Fly   441 RAKLPKKRRRVLPVEQPRQPRLPGAPGGVSGCGTPGSGPH 480
            :.|||||:::.:    ||.|:| |:|   :.|.:..:.||
Frog   518 KQKLPKKKKKHI----PRPPQL-GSP---NYCKSVVNSPH 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585
		BTB_2	27..117	CDD:280393
		Ion_trans	244..439	CDD:278921	115/204 (56%)
		Ion_trans_2	355..429	CDD:285168	53/80 (66%)
kcnc1	XP_031756512.1	LLB_putidacin	<49..>94	CDD:411188
kcnc1	XP_031756512.1	Ion_trans	259..516	CDD:395416	131/257 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	247	1.000	Domainoid score	I2104
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	1	1.000	-	-		FOG0000990
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.110