DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcns3

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_031758930.1	Gene:	kcns3 / 100497261	XenbaseID:	XB-GENE-952059	Length:	490	Species:	Xenopus tropicalis

Alignment Length:	444	Identity:	143/444 - (32%)
Similarity:	229/444 - (51%)	Gaps:	58/444 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRL---------TEALANYDPILNEYFFDRHPGVF 77
            :.|..|.|||||.:....:.||.:.|.|||.:|         .|...:|:....||:|||:|.:|
Frog    12 NEEELVKLNVGGFKQSVDQKTLLRFPHTRLGKLLNCRSEEAILELCDDYNVADKEYYFDRNPSLF 76

  Fly    78 AQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHR--------DTQETLAV 134
            ..:||:|.|||||...::|...|.:|:|:||::...::.||...|.:.:        |.:..:..
Frog    77 RYILNFYYTGKLHVMEELCVFSFSQEIEYWGINELFIDSCCSNKYQEKKEIIAEKDWDQKSDIIS 141

  Fly   135 LDRLDLDTEKPSEEEL----ARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVS 195
            |.....|.....|.||    ..|||              :::.:||...:.|..|.:||...:.|
Frog   142 LGSSSSDQSSVFERELEMFDTLKFG--------------DIRRKIWIRLENPAYSLSAKLFAIAS 192

  Fly   196 VFFICISILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFE 260
            :..:..||::.|:.:.|:.:        ...||       |:...:..:|  .:|.||..|||.|
Frog   193 LSVVLTSIVAMCIHSMPEFK--------KLDAN-------DRELEDPVLA--VVEIVCIIWFTSE 240

  Fly   261 ILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVL---QRFASHLEN-ADILEFFSIIRIMRLF 321
            :::|.|.:|::.:|.|:.:||||:::.:.||..||:   ......:|| ..:::...::||.|:.
Frog   241 LVIRLIVAPSQKKFWKNPMNIIDFVSIIPFYATLVVDVNDEENEGIENMGKVVQILRLMRIFRIL 305

  Fly   322 KLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWA 386
            ||.|||.||:.|..|.:.|..|:.||:.||.:||.||:.||||.|:  ....:..:|||:..|||
Frog   306 KLARHSVGLRSLGATLKHSYHEVGLLLLFLAVGISIFSVLVYYVEK--DEDQSGLHSIPMCWWWA 368

  Fly   387 LVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQA 440
            .::||||||||..|.|..|..||.:|.:.|:|.:|||:.:|.:.|:.||...:|
Frog   369 TISMTTVGYGDTHPVTLFGKLVGTVCIICGILVVALPITIIFNKFSKYYQKQKA 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	39/106 (37%)
		BTB_2	27..117	CDD:280393	36/98 (37%)
		Ion_trans	244..439	CDD:278921	79/198 (40%)
		Ion_trans_2	355..429	CDD:285168	34/73 (47%)
kcns3	XP_031758930.1	BTB_POZ_KCNS3	15..122	CDD:349735	38/106 (36%)
kcns3	XP_031758930.1	Ion_trans	185..421	CDD:395416	89/254 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920