DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcnc4

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_002933043.1	Gene:	kcnc4 / 100492941	XenbaseID:	XB-GENE-6032635	Length:	598	Species:	Xenopus tropicalis

Alignment Length:	449	Identity:	223/449 - (49%)
Similarity:	299/449 - (66%)	Gaps:	23/449 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRL----TEALANYDPILNEYFFDRHPGVFAQVLN 82
            :...::.:||||.||||||:||:.:|.|||:.|    |.:.:..|....|:|||||||:|:.|||
Frog    33 EDSGKITINVGGTRHETYKSTLRTLPGTRLAWLADPDTASNSESDSQRTEFFFDRHPGIFSYVLN 97

  Fly    83 YYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLD-LDTEKPS 146
            ||||||||.|.|:|||||||||.|||:|...|||||||||.||||.:|.|.:.:.:: .|.|:.:
Frog    98 YYRTGKLHCPADICGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFENVEPEDGEEEN 162

  Fly   147 EEELARKFGFEE--DYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLK 209
            :.........||  |..:|.   |:..:|::|:||::||||.||:.:..||:|||.:||.:|||:
Frog   163 KGSSPELLCIEERTDRSRGC---WKVWQPKMWALFEDPYSSRAARVVAFVSLFFILMSITTFCLE 224

  Fly   210 THPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEF 274
            ||....|.  ||:|.....|:....|...:........|||.||..|||.|.|||.|..|:|..|
Frog   225 THESFIVD--RNVTETVTIGNMTEILVVREVETEPILTYIEGVCVFWFTLEFLVRIICCPDKVFF 287

  Fly   275 IKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFFSI---IRIMRLFKLTRHSSGLKILIQT 336
            :|:.:||||::|.|.||:::.|...:|.... |:|.|..:   :||:|:||||||..||::|..|
Frog   288 VKNLLNIIDFVAILPFYLEVGLSGLSSKAAR-DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHT 351

  Fly   337 FRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNP-------HNDFNSIPLGLWWALVTMTTVG 394
            .|||..|..||:.||.||::|||:::||||||..||       |..|.:||:|.|||:|||||:|
Frog   352 LRASTNEFLLLIIFLALGVLIFATMIYYAERIGANPTDPSGSNHTHFKNIPIGFWWAVVTMTTLG 416

  Fly   395 YGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLP 453
            ||||.|:|:.||.||||||||||||||:||||||:||.||||...|:.|||||:::.:|
Frog   417 YGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHVP 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	63/101 (62%)
		BTB_2	27..117	CDD:280393	56/93 (60%)
		Ion_trans	244..439	CDD:278921	112/204 (55%)
		Ion_trans_2	355..429	CDD:285168	52/80 (65%)
kcnc4	XP_002933043.1	Potassium_chann	1..29	CDD:314363
		BTB_POZ	34..150	CDD:365784	69/115 (60%)
		Ion_trans	203..461	CDD:366146	131/260 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	247	1.000	Domainoid score	I2104
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	458	1.000	Inparanoid score	I1532
OMA	1	1.010	-	-		QHG48788
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48109
Panther	1	1.100	-	-	LDO	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3268
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.110