DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcnd1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_031747765.1	Gene:	kcnd1 / 100488387	XenbaseID:	XB-GENE-6047565	Length:	631	Species:	Xenopus tropicalis

Alignment Length:	454	Identity:	163/454 - (35%)
Similarity:	242/454 - (53%)	Gaps:	50/454 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MDSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYR 85
            |.|:..:|:||.|.:.:|:|.||.:.|.|.|.. ||....::....||||||.|.:|..:||:||
Frog    36 MKSDEILVVNVSGRKFQTWKNTLDRYPDTLLGS-TEKDFFFNQDTQEYFFDRDPEMFRHILNFYR 99

  Fly    86 TGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEEL 150
            |||||||...|...|:|||.|:|:....:..||...|...:...     |:||..||    |.|.
Frog   100 TGKLHYPRHECIQAFDEELSFYGIIPEIIGDCCLEEYRDRKKEN-----LERLAEDT----EAET 155

  Fly   151 ARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMR 215
            |.......|         ...:.|:|..|:.|::|..|.....|:.|||.:|:::..::|.| .|
Frog   156 AGDTPLPPD---------STFRQRLWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVP-CR 210

  Fly   216 VPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVN 280
            .|..|...:......|            :||..::..|...||||.|:|..::|::.:|::|.::
Frog   211 PPAGRLKELPCGEKYN------------LAFVCMDTACVLIFTFEYLMRLFAAPSRCKFMRSVMS 263

  Fly   281 IIDYIATLSFYIDLVLQRFASHLENADILEFF---SIIRIMRLFKLTRHSSGLKILIQTFRASAK 342
            |||.:|.:.|||.||:.      ||.::...|   .:.|:.|:||.:|||.||:||..|.::.|.
Frog   264 IIDVVAIMPFYIGLVMP------ENENVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCAS 322

  Fly   343 ELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMF 407
            ||..|:|.|.:.|:|||::::|||:  ......|.|||...|:.:|||||:|||||.|.|..|..
Frog   323 ELGFLLFSLTMAIIIFATVMFYAEK--GTSKTKFTSIPAAFWYTIVTMTTLGYGDMVPDTIAGKI 385

  Fly   408 VGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAPGGVSG 471
            .|::|:|:|||.||||||||||||:..| |...||...:.::::      |..|:..|....:|
Frog   386 FGSICSLSGVLVIALPVPVIVSNFSRIY-HQNQRADKRRAQQKI------RLARIRLAKSNTTG 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	42/97 (43%)
		BTB_2	27..117	CDD:280393	39/89 (44%)
		Ion_trans	244..439	CDD:278921	87/197 (44%)
		Ion_trans_2	355..429	CDD:285168	39/73 (53%)
kcnd1	XP_031747765.1	BTB_POZ_KCND1	6..143	CDD:349724	44/107 (41%)
		Ion_trans	184..415	CDD:395416	98/252 (39%)
		DUF3399	445..542	CDD:403174
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000