DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcnv1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_002939028.1	Gene:	kcnv1 / 100487006	XenbaseID:	XB-GENE-956997	Length:	503	Species:	Xenopus tropicalis

Alignment Length:	424	Identity:	146/424 - (34%)
Similarity:	224/424 - (52%)	Gaps:	54/424 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ENRVVLNVGGIRHETYKATLKKIPATRLSRLT--------EALANYDPILNEYFFDRHPGVFAQV 80
            ::.:.:||||.|.......|...|.|||.||.        |...:.:.:.|||||||...:|..:
Frog    58 KDHLTINVGGSRFILSHKVLSNHPETRLGRLVSSGGQEVYELCDDANLMDNEYFFDRSSQMFKYI 122

  Fly    81 LNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKP 145
            :|:|:||.||...::|...|.:|:::||:|...::.||...|.:.:...|:|.:         |.
Frog   123 MNFYKTGHLHVMEELCAVSFLQEIQYWGIDELNIDLCCRERYYRKKLMSESLDI---------KK 178

  Fly   146 SEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKT 210
            .|||:..    ||:.:.|.:  ::..:..:|.:.::|.||.||||.|.:|:.||.|||.:..|
Frog   179 DEEEIEA----EEEDFSGVV--FEHFRQTLWDILEKPGSSVAAKTFGTLSMTFIVISIANMVL-- 235

  Fly   211 HPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFI 275
                         :.:...|    :|....||      :|.:|..|||.|:.:||:...:|..|:
Frog   236 -------------ISSEMNS----IDPPLLNA------LEYICITWFTLELALRFLCVKHKCRFL 277

  Fly   276 KSSVNIIDYIATLSFYIDLVLQRF---ASHLENAD-ILEFFSIIRIMRLFKLTRHSSGLKILIQT 336
            :|.|||||.:|.|.|||.|:::..   ::.|||.. |::...::|.:|:.||.|||:|||.|..|
Frog   278 RSVVNIIDIVAILPFYITLIVENLYGESTELENVGRIVQSLRLLRSLRMLKLGRHSTGLKSLGMT 342

  Fly   337 FRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPK 401
            .....:|:.||:.||.:||.||::|.|..|...|:  ..|.|:|...|||..:||||||||:.|.
Frog   343 IAQCYEEVGLLLLFLSVGISIFSALEYAVEHNIPD--TTFTSVPNAWWWATTSMTTVGYGDIRPD 405

  Fly   402 TYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY 435
            |..|..|..||.|:|:|.:|||:.:|...||..|
Frog   406 TTFGKIVAFLCILSGILVLALPIAIINDRFAACY 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	36/105 (34%)
		BTB_2	27..117	CDD:280393	33/97 (34%)
		Ion_trans	244..439	CDD:278921	81/196 (41%)
		Ion_trans_2	355..429	CDD:285168	34/73 (47%)
kcnv1	XP_002939028.1	BTB_POZ_KCNV1	61..169	CDD:349731	36/107 (34%)
kcnv1	XP_002939028.1	Ion_trans	215..439	CDD:366146	95/250 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010