DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcnc1b

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_005174318.1	Gene:	kcnc1b / 100334453	ZFINID:	ZDB-GENE-080414-3	Length:	598	Species:	Danio rerio

Alignment Length:	492	Identity:	235/492 - (47%)
Similarity:	314/492 - (63%)	Gaps:	44/492 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALA----NYDPILNEYFFDRHPGVFAQVLN 82
            |.::|:|:|||||:|:||::||:.:|.||||.|.|..|    :||..:.|:||||||.|||.:||
Zfish     5 DDKDRIVINVGGIKHQTYRSTLRTLPGTRLSWLAEPDAPNNFDYDANIGEFFFDRHPSVFAHILN 69

  Fly    83 YYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVL--DRLDLDTEKP 145
            ||||||||.|.||||||:||||.|||:|...|||||||||.|||:.:|.|...  ..|||..:.|
Zfish    70 YYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHREAEEALDSFTGGALDLGHDDP 134

  Fly   146 SEE------------ELARKF--GFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSV 196
            ..|            |:.|:.  |...|...|..|.||:   :.|:||::||||..|:.:...|:
Zfish   135 EPEGVVEAAEGDEGVEMTRRLAQGDSPDNRSGRWSRWQK---KAWALFEDPYSSKYARWVAFASL 196

  Fly   197 FFICISILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEI 261
            |||.:||.:|||:||......|.|..|....|.:......:|:|...:.  |||.||..|||||.
Zfish   197 FFILVSITTFCLETHEAFNPIINRTETYMEGNETVERIFPETETMVQLT--YIEGVCVVWFTFEF 259

  Fly   262 LVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFFSI---IRIMRLFKL 323
            ::|..:.|:|.:|:::::||||::|.|.||:::.|...:|.... |:|.|..:   :||:|:|||
Zfish   260 IIRVTTCPDKLKFLRNTLNIIDFVAILPFYLEVGLSGLSSKAAK-DVLGFLRVVRFVRILRIFKL 323

  Fly   324 TRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHND--------FNSIP 380
            |||..||::|..|.|||..|..||:.||.||::|||:::||||||..|| ||        |.:||
Zfish   324 TRHFVGLRVLGHTLRASTNEFILLIIFLALGVLIFATMIYYAERIGRNP-NDPDASSDTHFKNIP 387

  Fly   381 LGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLP 445
            :|.|||:|||||:|||||.|:|..||.||||||||||||||:||||||:||.||||...|:.|||
Zfish   388 IGFWWAVVTMTTLGYGDMYPQTTSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLP 452

  Fly   446 KKRRRVLPVEQPRQPRLPGAPGGV-SGCGTPGSGPHS 481
            ||:.:.:     |:|.|.|:|... |...:|....||
Zfish   453 KKKNKHI-----RRPPLLGSPNYCRSAVNSPRPSTHS 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	65/101 (64%)
		BTB_2	27..117	CDD:280393	58/93 (62%)
		Ion_trans	244..439	CDD:278921	110/205 (54%)
		Ion_trans_2	355..429	CDD:285168	53/81 (65%)
kcnc1b	XP_005174318.1	BTB	10..112	CDD:197585	65/101 (64%)
		BTB_2	10..104	CDD:280393	58/93 (62%)
		Ion_trans	230..446	CDD:278921	112/219 (51%)
		Ion_trans_2	<389..436	CDD:285168	37/46 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2066
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1537
OMA	1	1.010	-	-		QHG48788
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	1	1.000	-	-		FOG0000990
OrthoInspector	1	1.000	-	-		otm25615
orthoMCL	1	0.900	-	-		OOG6_102927
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840