DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and kcnf1b

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_005157014.1	Gene:	kcnf1b / 100334378	ZFINID:	ZDB-GENE-090312-39	Length:	484	Species:	Danio rerio

Alignment Length:	492	Identity:	166/492 - (33%)
Similarity:	245/492 - (49%)	Gaps:	69/492 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTYIPKKMQHYAHAAMNLINMDSENRVVLNVGGIRHETYKATLKKIPATRLSRL----------- 54
            |..:|:  ..:||.  |..:...|..:.:|:||:|.......|.:.|.:||:.|
Zfish     1 MWTLPR--TRFAHC--NSSSSSDEKEIAVNIGGVRLVLCGDILNRYPDSRLAELVNCPTRSFDVI 61

  Fly    55 TEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCW 119
            :....:|||...|::|||.|..|..::..|..|::|....:|...|.:|:|||.:|.:.::.||.
Zfish    62 SSLCDDYDPGKREFYFDRDPDSFKCIVEVYYFGEVHMKRGICPICFIKEMEFWKIDLSYLDECCK 126

  Fly   120 MTYTQHRDTQETLA-----VLDRLDLDTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLF 179
            ...|:..:....:|     :||.|:.|   |:.....|               ||:.   :|.|.
Zfish   127 SNLTEKEEELAEIADKVKLILDDLECD---PAVSRTER---------------WQKF---VWKLM 170

  Fly   180 DEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHI 244
            ::|.||..|:.|.|||..||.||.:..||.|.||::|           ..|.|..::....:|
Zfish   171 EKPESSLPARVIAVVSFLFILISSVVMCLGTLPDLQV-----------EDSEGNRVEHPSLDA-- 222

  Fly   245 AFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFAS---HLENA 306
                ||..|..|||.|.::|..|||||..|..|.:|:||::|.|.||:.|||....:   .|.|.
Zfish   223 ----IETACIGWFTVEYVLRLASSPNKLRFALSFMNMIDFLAVLPFYVVLVLTCLGTAMMELVNV 283

  Fly   307 -DILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQP 370
             ..::...|:||.|:|||.||||||:.|....:.|.|||.||:.::.:||.:|::|.|..|  |.
Zfish   284 QQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYMGVGIFVFSALGYTME--QS 346

  Fly   371 NPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY 435
            :|...|.|||...|||::|||||||||:.|||.:|....|:..|.||:.||||:..|::||.:||
Zfish   347 HPETLFRSIPQSFWWAIITMTTVGYGDIYPKTTLGRCNAAISFLCGVIAIALPIHPIINNFVIYY 411

  Fly   436 S-----HTQARAKLPKKRRRVLPVEQPRQPRLPGAPG 467
            :     .|.|:.:|.....|.|.:......|...|||
Zfish   412 NKQKVLETAAKHELELMELRALELTVRSASRRSDAPG 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	31/108 (29%)
		BTB_2	27..117	CDD:280393	28/100 (28%)
		Ion_trans	244..439	CDD:278921	88/203 (43%)
		Ion_trans_2	355..429	CDD:285168	36/73 (49%)
kcnf1b	XP_005157014.1	BTB	23..129	CDD:197585	30/105 (29%)
		BTB	23..124	CDD:295341	28/100 (28%)
		Ion_trans	220..415	CDD:278921	89/202 (44%)
		Ion_trans_2	331..398	CDD:285168	33/68 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920