DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and kcng1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001096675.1	Gene:	kcng1 / 100125206	XenbaseID:	XB-GENE-1011042	Length:	508	Species:	Xenopus tropicalis

Alignment Length:	452	Identity:	140/452 - (30%)
Similarity:	224/452 - (49%)	Gaps:	59/452 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPIL----------NEYFFDRHPGV 76
            |.::..::||||.|:.....||::.|.|||.:| :..:|:|.||          ||:||||:||.
Frog    59 DRKHHAIINVGGFRYLLPWTTLEEFPLTRLGQL-KLCSNFDEILSICDDYDVTCNEFFFDRNPGA 122

  Fly    77 FAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLD 141
            |..:|.:.:.|||....::|...|:|||.:||::.:.:|.||...|.|..:....|.:.:...::
Frog   123 FRTILTFLQVGKLRLLREMCALSFQEELLYWGIEEDNLEWCCKRRYIQKMEEFAELNLREEELIE 187

  Fly   142 TEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSF 206
            .|..||.|...|...              ....:..:.::|.|....|....:||.|:.|:.::.
Frog   188 NENASEPEDESKLDI--------------CMRHLGDMVEKPQSGLPGKIFACLSVLFVTITAVNL 238

  Fly   207 CLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNK 271
            .:.|.||:|....:.:..|....                .|.:|.||..||:.|.|:|||.:|:|
Frog   239 SISTMPDLREEEEKGVCSKMCYN----------------IFIVESVCVGWFSLEFLLRFIQAPSK 287

  Fly   272 WEFIKSSVNIIDYIATLSFYIDLVLQRFA----------SHLENAD-ILEFFSIIRIMRLFKLTR 325
            :.||:..:|:||.:|.|.:||.||:...:          |:|:... :|.....:||:.:.:|.|
Frog   288 FAFIRRPLNLIDIVAILPYYITLVVDNTSDGQKKPGSGNSYLDKVGLVLRILRALRILYVMRLAR 352

  Fly   326 HSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTM 390
            ||.||:.|..|.|...:|..||:.||.:.|.:||.|:|..|. :.....:|.|||...|||::||
Frog   353 HSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYLIEN-EMADSQEFTSIPACYWWAVITM 416

  Fly   391 TTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVL 452
            ||||||||.|::..|..|.....|:|:|.:|.||..|...|:..|      .:|.:::.|::
Frog   417 TTVGYGDMVPRSIPGQVVALSSILSGILLMAFPVTSIFHTFSRSY------IELKQEQERLM 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	40/107 (37%)
		BTB_2	27..117	CDD:280393	37/99 (37%)
		Ion_trans	244..439	CDD:278921	78/205 (38%)
		Ion_trans_2	355..429	CDD:285168	33/73 (45%)
kcng1	NP_001096675.1	BTB_POZ_KCNG1_2	59..172	CDD:349728	42/113 (37%)
kcng1	NP_001096675.1	Ion_trans	221..461	CDD:366146	87/256 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000