DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shaw and kcnd1

DIOPT Version :9

Sequence 1:NP_001137782.1 Gene:Shaw / 33599 FlyBaseID:FBgn0003386 Length:619 Species:Drosophila melanogaster
Sequence 2:NP_001119942.1 Gene:kcnd1 / 100001681 ZFINID:ZDB-GENE-081105-40 Length:632 Species:Danio rerio


Alignment Length:453 Identity:158/453 - (34%)
Similarity:240/453 - (52%) Gaps:72/453 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 MDSENR----VVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVL 81
            :|.:||    :.:||.|:|.:|:|.||.:.|.|.|.. :|....|:....||||||.|.:|..:|
Zfish    32 IDKKNRNDEILFVNVSGLRFQTWKNTLDRYPDTLLGS-SEKEFFYNEDTQEYFFDRDPEMFRHIL 95

  Fly    82 NYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTY-TQHRDTQETLAVLDRLDLDTEKP 145
            |:||||:||||...|...|:|||.|:|:..:.:..||...| .:.::.||.|||....::.|:.|
Zfish    96 NFYRTGRLHYPRQECIQAFDEELAFYGIVPDIIGDCCMEEYRDRKKENQERLAVDTEAEMATDTP 160

  Fly   146 SEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKT 210
            .......                   :.|:|..|:.|::|..|.....|:.|||.:|:::     
Zfish   161 LPPHSTH-------------------RERLWRAFENPHTSTMALVFYYVTGFFIAVSVIA----- 201

  Fly   211 HPDMRVPIVRNITVKTANGSN-----GWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPN 270
                  .:|..:..:...||.     |       ....:|||.::..|...||||.|:|..::|:
Zfish   202 ------NVVETVPCRPLKGSKKDLPCG-------EKYSLAFFCMDTACVLIFTFEYLMRLFAAPS 253

  Fly   271 KWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFF---SIIRIMRLFKLTRHSSGLKI 332
            :.:|::|.:::||.:|.:.:||.||:.      ||.|:...|   .:.|:.|:||.:|||.||:|
Zfish   254 RCKFMRSVMSVIDVVAIMPYYIGLVMP------ENEDVSGAFVTLRVFRVFRIFKFSRHSQGLRI 312

  Fly   333 LIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGD 397
            |..|.::.|.||..|:|.|.:.|:|||::::|||:  .....:|.|||...|:.:|||||:||||
Zfish   313 LGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEK--GTKGTNFTSIPASFWYTIVTMTTLGYGD 375

  Fly   398 MAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQ-------------ARAKLPKK 447
            |.|.|..|...|::|:|:|||.||||||||||||:..|...|             ||.:|.||
Zfish   376 MVPNTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKMRAQQKVRLARIRLAKK 438

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawNP_001137782.1 BTB 27..125 CDD:197585 41/98 (42%)
BTB_2 27..117 CDD:280393 38/89 (43%)
Ion_trans 244..439 CDD:278921 86/197 (44%)
Ion_trans_2 355..429 CDD:285168 39/73 (53%)
kcnd1NP_001119942.1 Shal-type 3..28 CDD:288455
BTB_2 42..131 CDD:280393 38/89 (43%)
BTB 44..132 CDD:197585 38/88 (43%)
Ion_trans 217..415 CDD:278921 87/212 (41%)
Ion_trans_2 331..411 CDD:285168 44/81 (54%)
DUF3399 445..542 CDD:288712
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.810

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