Protein Alignment HTR3A and nAChRbeta1

DIOPT Version :9

• Sequence 1: NP_998786.3
• Gene: HTR3A / 3359
• HGNCID: 5297
• Length: 510
• Species: Homo sapiens
• Sequence 2: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 548
• Identity: 138/548 - (25%)
• Similarity: 239/548 - (43%)
• Gaps: 104/548 - (18%)

Human     4 WVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 68
            |:..::|.|:..:|::..|...          ||...|...|.|.:|||::..:...|...:...
  Fly     8 WLLCSILVLVAFSLVSASEDEE----------RLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFV 62

Human    69 AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPN 133
            .::||:||||::.:.:|.|..|.|..|||:..|:..|..|.:|.|.:|.|||::  |.:...:..
  Fly    63 QLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVL--FNNADGNYE 125

Human   134 IPY---VYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEK 195
            :.|   |.|...|||....|....::|::|:..||||.|.|.:.|.||......::::|:.  .|
  Fly   126 VRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYN--NK 188

Human   196 VKSDRSVFMNQGEWELLGVLPYFREFSMESSN-YYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVM 259
            ...|.|.:...|.|:::.|..|...:..:|:: ...::.||::|||:.|||.|:|:||::.:..:
  Fly   189 NFVDLSDYWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFL 253

Human   260 DIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSH 324
            .::.||||..:||:|:..|::||...|||::||..||.|::..|||.|
  Fly   254 CVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAK----------------- 301

Human   325 LLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLE-------- 381
                           |.:....:..:|:..|:.|:....:......:|.::|.:.|.
  Fly   302 ---------------YLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFM 351

Human   382 ------RIAWLLCLREQSTSQRPPAT--SQATKTDDCSAMGNHCSHM------------------ 420
                  |:.|::.:...|....|..:  |.|......||:|...|.|
  Fly   352 KRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRK 416

Human   421 ---GGP--------QDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDW 474
               ||.        ::.|.|.....||     |||.|.    :.:..|.:.|...|...:...||
  Fly   417 VNSGGELGLGDGCRRESESSDSILLSP-----EASKAT----EAVEFIAEHLRNEDLYIQTREDW 472

Human   475 LRVGSVLDKLLFHIYLLAVLAYSITLVM 502
            ..|..|:|:|..:|:.:...|.::.::|
  Fly   473 KYVAMVIDRLQLYIFFIVTTAGTVGILM 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR3A	NP_998786.3	LIC	23..504	CDD:273305	133/529 (25%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	137/546 (25%)
		Neur_chan_LBD	28..236	CDD:280998	64/221 (29%)
		Neur_chan_memb	243..498	CDD:280999	64/295 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810