DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sob and OSR2

DIOPT Version :9

Sequence 1:	NP_476882.1	Gene:	sob / 33581	FlyBaseID:	FBgn0004892	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_001273770.1	Gene:	OSR2 / 116039	HGNCID:	15830	Length:	433	Species:	Homo sapiens

Alignment Length:	339	Identity:	162/339 - (47%)
Similarity:	196/339 - (57%)	Gaps:	53/339 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 PPLTAATASAAATSS-PSSNNSNSTSTPTTSKCVP---------LPSIGTVSAAVAAAAAAAAAA 286
            ||.:.:.......|: |:|....|.:.|......|         |.::.|..|.|.........:
Human   101 PPASDSWKKGLVPSAPPASRKMGSKALPAPIPLHPSLQLTNYSFLQAVNTFPATVDHLQGLYGLS 165

  Fly   287 ASQQAALD-------------CATAAELAAECDLPLLDGE---DALSFEAGDLDSSYGSFMFNPS 335
            |.|...::             .:|..|:||.  ..|:|..   .||.|.         :.:|:|.
Human   166 AVQTMHMNHWTLGYPNVHEITRSTITEMAAA--QGLVDARFPFPALPFT---------THLFHPK 219

  Fly   336 AFSQAETDSALH---------SLQATMYQD---KMSVISGAAGGVGAGAVGGLEEAGSSAAAAAA 388
            ..:.|....|||         :|.....|:   ||..:|..:.|:|: .:.||.:.......:..
Human   220 QGAIAHVLPALHKDRPRFDFANLAVAATQEDPPKMGDLSKLSPGLGS-PISGLSKLTPDRKPSRG 283

  Fly   389 Q---RSKKQFICKFCNRQFTKSYNLLIHERTHTDERPYSCDICGKAFRRQDHLRDHRYIHSKEKP 450
            :   ::||:||||||.|.||||||||||||||||||||:||||.|||||||||||||||||||||
Human   284 RLPSKTKKEFICKFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKP 348

  Fly   451 FKCAECGKGFCQSRTLAVHKILHMEESPHKCPVCNRSFNQRSNLKTHLLTHTDIKPYNCASCGKV 515
            |||.||||||||||||||||.|||:|||||||.|.|:||||||||||||||||||||:|..||||
Human   349 FKCQECGKGFCQSRTLAVHKTLHMQESPHKCPTCGRTFNQRSNLKTHLLTHTDIKPYSCEQCGKV 413

  Fly   516 FRRNCDLRRHSLTH 529
            ||||||||||||||
Human   414 FRRNCDLRRHSLTH 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sob	NP_476882.1	COG5048	<389..529	CDD:227381	122/142 (86%)
		C2H2 Zn finger	397..417	CDD:275368	17/19 (89%)
		zf-H2C2_2	409..434	CDD:290200	22/24 (92%)
		C2H2 Zn finger	425..445	CDD:275368	18/19 (95%)
		zf-H2C2_2	437..460	CDD:290200	21/22 (95%)
		C2H2 Zn finger	453..473	CDD:275368	17/19 (89%)
		zf-C2H2	479..501	CDD:278523	18/21 (86%)
		C2H2 Zn finger	481..501	CDD:275368	16/19 (84%)
		zf-H2C2_2	493..518	CDD:290200	21/24 (88%)
		C2H2 Zn finger	509..529	CDD:275368	17/19 (89%)
OSR2	NP_001273770.1	COG5048	<293..428	CDD:227381	122/135 (90%)
		C2H2 Zn finger	295..315	CDD:275368	17/19 (89%)
		zf-H2C2_2	307..332	CDD:290200	22/24 (92%)
		C2H2 Zn finger	323..343	CDD:275368	18/19 (95%)
		zf-H2C2_2	335..358	CDD:290200	21/22 (95%)
		C2H2 Zn finger	351..371	CDD:275368	17/19 (89%)
		zf-C2H2	377..399	CDD:278523	18/21 (86%)
		C2H2 Zn finger	379..399	CDD:275368	16/19 (84%)
		zf-H2C2_2	391..416	CDD:290200	21/24 (88%)
		C2H2 Zn finger	407..427	CDD:275368	17/19 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11341
eggNOG	1	0.900	-	-		E33208_3B9IA
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000748
OrthoInspector	1	1.000	-	-		mtm8449
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1664
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.870