DRSC/TRiP Functional Genomics Resources

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Protein Alignment HTR2C and Dop1R2

DIOPT Version :10

Sequence 1:NP_000859.2 Gene:HTR2C / 3358 HGNCID:5295 Length:458 Species:Homo sapiens
Sequence 2:NP_001263072.1 Gene:Dop1R2 / 43484 FlyBaseID:FBgn0266137 Length:807 Species:Drosophila melanogaster


Alignment Length:464 Identity:139/464 - (29%)
Similarity:201/464 - (43%) Gaps:120/464 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    26 SVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALS----------------IVIIIIMTIGGNILV 74
            :.|..:|.::.....:.||....|:     |.||                :.:....|:.||.||
  Fly    70 TTSATSATLSPAMVATGGGGTTTPE-----PDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLV 129

Human    75 IMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFST 139
            |:||..|:.||.|||||:.|||:||.||||:|||.|.|..:.:..|......|.:|.||||||||
  Fly   130 ILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFST 194

Human   140 ASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPV--IGLRDEEKVFV 202
            |||::||.||||||.||.:|..:....:..:|...||.||..|..:|.|..|  ...||.|   :
  Fly   195 ASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARDGE---M 256

Human   203 NNTTCVLNDP-NFVLIGSFVAFFIPLTIMVITYCLTIY-----------VLRRQALM-------- 247
            ....|...:. .:::..|.::|::||.:||.||| .||           :..:|.||        
  Fly   257 PAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYC-RIYRAAVIQTRSLKIGTKQVLMASGELQLT 320

Human   248 --------------------------------LLHGHT------------------EEPPGLSLD 262
                                            |.|.|:                  |||.     
  Fly   321 LRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPD----- 380

Human   263 FLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPF 327
                      :|..||..|......|...|.......:.....|:||:|.||||..||:|.|.||
  Fly   381 ----------DEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPF 435

Human   328 FITNILSVLCEKSCNQKLMEKLLNVFV-WIGYVCSGINPLVYTLFNKIYRRAFSNYL--RCNYKV 389
            |:.|:||..|.:....   |::::..| |:|::.|.:||::|..:::.:||||...|  .|..|:
  Fly   436 FVVNLLSGFCIECIEH---EEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCCPRKI 497

Human   390 EKK--PPVR 396
            .:|  |.:|
  Fly   498 RRKYQPTMR 506

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HTR2CNP_000859.2 7tmA_5-HT2C 54..385 CDD:341346 129/421 (31%)
TM helix 1 55..81 CDD:341346 11/41 (27%)
TM helix 2 88..114 CDD:341346 18/25 (72%)
TM helix 3 127..157 CDD:341346 22/29 (76%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 151..153 1/1 (100%)
TM helix 4 169..192 CDD:341346 9/24 (38%)
TM helix 5 211..240 CDD:341346 11/40 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..301 6/26 (23%)
TM helix 6 304..334 CDD:341346 16/29 (55%)
TM helix 7 347..372 CDD:341346 8/25 (32%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 364..368 2/3 (67%)
PDZ-binding 456..458
Dop1R2NP_001263072.1 7tmA_Dop1R2-like 122..485 CDD:320195 123/384 (32%)
TM helix 2 143..169 CDD:320195 18/25 (72%)
TM helix 3 182..212 CDD:320195 22/29 (76%)
TM helix 4 224..246 CDD:320195 8/21 (38%)
TM helix 5 266..295 CDD:320195 11/29 (38%)
TM helix 6 297..442 CDD:320195 31/159 (19%)
TM helix 7 453..478 CDD:320195 7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

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