DRSC/TRiP Functional Genomics Resources

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Protein Alignment HTR2C and Oct-TyrR

DIOPT Version :10

Sequence 1:NP_000859.2 Gene:HTR2C / 3358 HGNCID:5295 Length:458 Species:Homo sapiens
Sequence 2:NP_524419.2 Gene:Oct-TyrR / 42452 FlyBaseID:FBgn0004514 Length:601 Species:Drosophila melanogaster


Alignment Length:506 Identity:137/506 - (27%)
Similarity:210/506 - (41%) Gaps:179/506 - (35%)


- Green bases have known domain annotations that are detailed below.


Human    52 VQNW----PALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLL 112
            |..|    .||.:.:||::||.||||||::|...|.|....|:|::|||:||:.|.|||:|.:  
  Fly   104 VPEWEALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFN-- 166

Human   113 AILYDYV--WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKI 175
             :.|..:  |....:||.:|::.|||..|:||::||||:||||.||.:||.:::..:..:.::.|
  Fly   167 -VAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLI 230

Human   176 AIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVL-NDPNFVLIGSFVAFFIPLTIMVITYCLTIY 239
            :.||.:|:.:|.| |:||..|....|.:.|.|.| :...:|:..|..:|||||.||.|.| :.|:
  Fly   231 SGVWLLSLLISSP-PLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVY-IEIF 293

Human   240 VLRRQAL-----------MLLHGHTEEPPGLS--------------LDFLKCCKRNTA------- 272
            |..|:.|           :.|.....||...|              |....||.|:.|       
  Fly   294 VATRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMI 358

Human   273 --------------EEENSANP--NQD----------QNARRRKKKE----------RR------ 295
                          ::.:.|.|  |.|          :.:||.|.|:          |:      
  Fly   359 QNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSST 423

Human   296 ------------------------------------------PRGTMQ----------------- 301
                                                      |:|.:|                 
  Fly   424 CEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPP 488

Human   302 -------------------------------AINNERKASKVLGIVFFVFLIMWCPFFITNILSV 335
                                           :::.||:|::.|||:..||:|.|.|||:..::..
  Fly   489 QSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILP 553

Human   336 LCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCN 386
            .|:..|.   ..|..|...|:||:.||:||::||:||..|||||...|..|
  Fly   554 FCQTCCP---TNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLLGLN 601

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HTR2CNP_000859.2 7tmA_5-HT2C 54..385 CDD:341346 135/501 (27%)
TM helix 1 55..81 CDD:341346 14/29 (48%)
TM helix 2 88..114 CDD:341346 12/25 (48%)
TM helix 3 127..157 CDD:341346 17/29 (59%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 151..153 1/1 (100%)
TM helix 4 169..192 CDD:341346 7/22 (32%)
TM helix 5 211..240 CDD:341346 12/28 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..301 11/96 (11%)
TM helix 6 304..334 CDD:341346 13/29 (45%)
TM helix 7 347..372 CDD:341346 11/24 (46%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 364..368 2/3 (67%)
PDZ-binding 456..458
Oct-TyrRNP_524419.2 7tmA_tyramine_octopamine_R-like 110..>294 CDD:320188 76/188 (40%)
TM helix 1 111..137 CDD:320188 13/25 (52%)
TM helix 2 144..170 CDD:320188 12/28 (43%)
TM helix 3 182..212 CDD:320188 17/29 (59%)
TM helix 4 224..247 CDD:320188 7/23 (30%)
TM helix 5 266..294 CDD:320188 12/28 (43%)
7tm_GPCRs <519..594 CDD:475119 31/77 (40%)
TM helix 6 528..550 CDD:410628 10/21 (48%)
TM helix 7 562..587 CDD:410628 11/24 (46%)
Blue background indicates that the domain is not in the aligned region.

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