Protein Alignment HTR2C and Octalpha2R

DIOPT Version :10

• Sequence 1: NP_000859.2
• Gene: HTR2C / 3358
• HGNCID: 5295
• Length: 458
• Species: Homo sapiens
• Sequence 2: NP_001262715.1
• Gene: Octalpha2R / 42258
• FlyBaseID: FBgn0038653
• Length: 740
• Species: Drosophila melanogaster
• Alignment Length: 626
• Identity: 132/626 - (21%)
• Similarity: 208/626 - (33%)
• Gaps: 287/626 - (45%)

Human    42 DGGRFKFPDG--VQNWPALSIVIIIIMTI--GGNILVIMAVSMEKKLHNATNYFLMSLAIADMLV 102
            ||   ::|.|  :.:....||::.|:|.|  .||:|||:|::.||.|.|..|:|:.|||:||..:
  Fly   103 DG---RYPSGYTLTHIVIASIIVTILMIIIVVGNMLVIIAIATEKSLKNIQNWFIASLAVADFFL 164

Human   103 GLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNS 167
            ||::||.||...|..| |....:.|.:..::|||..|||||:||.||||||.:|...:::.:..:
  Fly   165 GLIIMPFSLANELMGY-WIFGSWWCDIHSAMDVLLCTASIMNLCLISLDRYWSITKAVDYLKSRT 228

Human   168 RTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNN---TTCVLN-DPNFVLIGSFVAFFIPLT 228
            ..:|.:.|..||.:|..:.:| |::|.    ||.:..   ..|.|: |..:||..:..:|:||..
  Fly   229 PARAAVMITAVWIMSALICIP-PLLGW----KVKMPEGPLPKCELSEDIGYVLYSALGSFYIPSC 288

Human   229 IMVITYCLTIYVLRRQALMLLHGH----------------------------------------- 252
            |||..|....:..:.:|...:..|
  Fly   289 IMVFVYIRIYFAAKARARRGIKKHPRKTNNEQVTSFTTAKKGTIPMPSSSGVSALQLHQQRQIAT 353

Human   253 TEEPP------------------------------------------------------------ 257
            .|.||
  Fly   354 IETPPNSASLPMQIPTVTMDLASDISTSEAGELEAVAAQTVLAYANPNGAGTNSVTVVSSGNGGP 418

Human   258 ----------------------------------------------------------------- 257
                                                                             
  Fly   419 GASGVPPSSPKETLQVSTIATGRVGLNVPVPPSMGSNSSINVLNNNNGTVAMDGGATAAGGGNGS 483

Human   258 ------------------------------GLSLDFL--------------KCC----------- 267
                                          |:..|.:              :|.
  Fly   484 AVATPGGLQQTGGNELRVSPIAGRCRALSVGVDTDMVSEFDPSSSDSGVVSRCAVVKPLKFRLCQ 548

Human   268 -----------KRNTAE-----EENS--ANPNQDQNARRRKK------------KERRPRGTMQ- 301
                       :||.|:     :::|  |:.||.|..:::::            |..:||...:
  Fly   549 PIFGRKSSNQQRRNEAKAAAKNQQSSGVASKNQQQQQQQQQQQVVKSELEPAIPKTPKPRDPEKE 613

Human   302 ----AINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSG 362
                |...|::|:.:||::...|:..|.|||...||...|...||  :.|....|..|:||:.|.
  Fly   614 KRRIARKKEKRATLILGLIMGSFIACWLPFFFLYILVPACSSHCN--IPESAFAVAFWLGYMNSA 676

Human   363 INPLVYTLFNKIYRRAFSNYL-----------RCNY-KVEK 391
            :||.:||:|||.:||||...|           ||.| .:||
  Fly   677 LNPAIYTIFNKDFRRAFRRILFKXCLAYVCCYRCVYASIEK 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR2C	NP_000859.2	7tmA_5-HT2C	54..385	CDD:341346	123/603 (20%)
		TM helix 1	55..81	CDD:341346	11/27 (41%)
		TM helix 2	88..114	CDD:341346	13/25 (52%)
		TM helix 3	127..157	CDD:341346	17/29 (59%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	151..153		1/1 (100%)
		TM helix 4	169..192	CDD:341346	7/22 (32%)
		TM helix 5	211..240	CDD:341346	10/28 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..301		8/40 (20%)
		TM helix 6	304..334	CDD:341346	10/29 (34%)
		TM helix 7	347..372	CDD:341346	10/24 (42%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	364..368		2/3 (67%)
		PDZ-binding	456..458
Octalpha2R	NP_001262715.1	7tmA_alpha2_AR	132..>307	CDD:320187	67/180 (37%)
		TM helix 2	150..176	CDD:320187	13/25 (52%)
		TM helix 3	188..218	CDD:320187	17/29 (59%)
		TM helix 4	230..253	CDD:320187	7/23 (30%)
		TM helix 5	271..300	CDD:320187	10/28 (36%)
		7tm_GPCRs	<616..693	CDD:475119	30/78 (38%)
		TM helix 6	626..648	CDD:410628	7/21 (33%)
		TM helix 7	661..686	CDD:410628	10/24 (42%)