Protein Alignment HTR2C and Dop1R1

DIOPT Version :10

• Sequence 1: NP_000859.2
• Gene: HTR2C / 3358
• HGNCID: 5295
• Length: 458
• Species: Homo sapiens
• Sequence 2: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Alignment Length: 386
• Identity: 116/386 - (30%)
• Similarity: 191/386 - (49%)
• Gaps: 75/386 - (19%)

Human    19 LVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKK 83
            :|.:....:|.|:.:|..||                     :.::|.:::.|||||.:|:..|:.
  Fly   115 IVGEEPEPLSLVSIVVVGIF---------------------LSVLIFLSVAGNILVCLAIYTERS 158

Human    84 LHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAI 148
            |....|.||.||||||:.|..|||..:.:..|..| |......|..|::.||:.|||||::||||
  Fly   159 LRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGY-WIFGAQFCDTWVAFDVMCSTASILNLCAI 222

Human   149 SLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVS-VPIPVIGLR--DEEKVFVNN----TT 206
            |:|||:.|::|:.:.|:.:|..|::.||.:|.::..|| |||. :|:.  |:..:|.:|    .|
  Fly   223 SMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPIS-LGIHRPDQPLIFEDNGKKYPT 286

Human   207 CVLN-DPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRN 270
            |.|: .|.:.::.|.::|:.|..:|:..|| .:|...::.:..:...|.  ||           .
  Fly   287 CALDLTPTYAVVSSCISFYFPCVVMIGIYC-RLYCYAQKHVKSIKAVTR--PG-----------E 337

Human   271 TAEEENSANPNQDQNARRRKKKERRPRGTMQAIN-------------NERKASKVLGIVFFVFLI 322
            .||             ::|.|..|||:...:...             ::.||:..:|::..||||
  Fly   338 VAE-------------KQRYKSIRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMGVFLI 389

Human   323 MWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYL 383
            .|.|||..||.:..| |:|   :..:...:..|:||..|..||::|::|||.:|.||...|
  Fly   390 CWVPFFCVNITAAFC-KTC---IGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRIL 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR2C	NP_000859.2	7tmA_5-HT2C	54..385	CDD:341346	110/351 (31%)
		TM helix 1	55..81	CDD:341346	7/25 (28%)
		TM helix 2	88..114	CDD:341346	13/25 (52%)
		TM helix 3	127..157	CDD:341346	17/29 (59%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	151..153		1/1 (100%)
		TM helix 4	169..192	CDD:341346	9/23 (39%)
		TM helix 5	211..240	CDD:341346	7/28 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..301		5/26 (19%)
		TM helix 6	304..334	CDD:341346	13/42 (31%)
		TM helix 7	347..372	CDD:341346	7/24 (29%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	364..368		2/3 (67%)
		PDZ-binding	456..458
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	110/365 (30%)
		TM helix 1	130..156	CDD:320193	10/46 (22%)
		TM helix 2	163..189	CDD:320193	13/25 (52%)
		TM helix 3	201..231	CDD:320193	17/29 (59%)
		TM helix 4	243..265	CDD:320193	8/21 (38%)
		TM helix 5	292..321	CDD:320193	8/29 (28%)
		TM helix 6	371..401	CDD:320193	13/29 (45%)
		TM helix 7	410..435	CDD:320193	7/24 (29%)