DRSC/TRiP Functional Genomics Resources

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Protein Alignment HTR2C and 5-HT2B

DIOPT Version :10

Sequence 1:NP_000859.2 Gene:HTR2C / 3358 HGNCID:5295 Length:458 Species:Homo sapiens
Sequence 2:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster


Alignment Length:888 Identity:166/888 - (18%)
Similarity:245/888 - (27%) Gaps:511/888 - (57%)


- Green bases have known domain annotations that are detailed below.


Human    18 LLVWQSDISVSPVAAIVTDIFNTSDGGRFK-------------FPDGVQNWPALSIVIIIIMTIG 69
            |::|:.| ......|..|...|.....|:.             .|....|:.||..:::::.|..
  Fly    26 LVLWEED-ETQRTTANATSRHNQLHVARWNATGNATISATFEDVPFDANNYWALLALVLVLGTAA 89

Human    70 GNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLD 134
            |||||.:|::.|::|.|.||||||||||.|::|.:|||||.:|.::..| :||....|..||.||
  Fly    90 GNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGY-FPLGSEHCLTWICLD 153

Human   135 VLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEK 199
            |||.||||||||.||:|||:::|.|:...|..:|.:..:||..||.:||.:|:|:.::..::...
  Fly   154 VLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHAS 218

Human   200 VFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQ-------------------- 244
            |.||. ||.:.||.:.|:||.|.|:|||.:|::|||||:.:|.||                    
  Fly   219 VLVNG-TCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASG 282

Human   245 ------------------------ALMLLHGHT-----------------------EEPP----- 257
                                    |..:||.|:                       :||.     
  Fly   283 WLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMT 347

Human   258 ----------------------------------------------------------------- 257
                                                                             
  Fly   348 ALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQH 412

Human   258 --------------------GLSLDFLKCCKRNTA------------------------------ 272
                                |||...|...:.:|.                              
  Fly   413 PAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKR 477

Human   273 ------------------------------------------------------------EEENS 277
                                                                        |||.|
  Fly   478 RRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEES 542

Human   278 ANPNQDQNAR------------------------------------------------------- 287
            |. .:||..:                                                       
  Fly   543 AQ-QKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAE 606

Human   288 ----------------------------------------------------------------- 287
                                                                             
  Fly   607 VKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHS 671

Human   288 ---------------------------RRK-------------KKERRPRG-------------- 298
                                       |||             ....|.||              
  Fly   672 AHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTP 736

Human   299 -----------------TMQAINN----------------------------------------- 305
                             |:::..|                                         
  Fly   737 TKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVIS 801

Human   306 ------------ERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGY 358
                        |:||:||||:|||.|:|:|.|||:.|:|..:|.: |.:::...:.:|..|:||
  Fly   802 RNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAE-CEERISHWVFDVVTWLGY 865

Human   359 VCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEK--KPPVRQIP 399
            ..|.:||:.||:|||::|:||...|.|.|....  :|...|.|
  Fly   866 ASSMVNPIFYTIFNKVFRQAFKKVLLCRYSSTSAWRPSRXQTP 908

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HTR2CNP_000859.2 7tmA_5-HT2C 54..385 CDD:341346 153/821 (19%)
TM helix 1 55..81 CDD:341346 9/25 (36%)
TM helix 2 88..114 CDD:341346 18/25 (72%)
TM helix 3 127..157 CDD:341346 21/29 (72%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 151..153 1/1 (100%)
TM helix 4 169..192 CDD:341346 8/22 (36%)
TM helix 5 211..240 CDD:341346 16/28 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..301 13/217 (6%)
TM helix 6 304..334 CDD:341346 18/82 (22%)
TM helix 7 347..372 CDD:341346 9/24 (38%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 364..368 2/3 (67%)
PDZ-binding 456..458
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 91/194 (47%)
TM helix 1 75..101 CDD:320433 9/25 (36%)
TM helix 2 108..134 CDD:320433 18/25 (72%)
TM helix 3 146..176 CDD:320433 21/29 (72%)
TM helix 4 188..211 CDD:320433 8/22 (36%)
TM helix 5 229..258 CDD:320433 16/28 (57%)
7tm_GPCRs <799..893 CDD:475119 36/94 (38%)
TM helix 6 818..840 CDD:410628 13/21 (62%)
TM helix 7 854..879 CDD:410628 9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

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