Protein Alignment HTR2C and 5-HT2A

DIOPT Version :10

• Sequence 1: NP_000859.2
• Gene: HTR2C / 3358
• HGNCID: 5295
• Length: 458
• Species: Homo sapiens
• Sequence 2: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Alignment Length: 655
• Identity: 160/655 - (24%)
• Similarity: 244/655 - (37%)
• Gaps: 282/655 - (43%)

Human     1 MVNLRN-AVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPD-GVQNWPALSIVII 63
            ::|:.| ::..||.:|..|    :..|.:..|.:.|:...|.     .|.| ....:..|.:.::
  Fly   238 IMNVTNTSLDMFLPNLTAL----NTTSTASTADMATEFAVTK-----SFLDYSPHGYDFLFLFVV 293

Human    64 IIMTIG--GNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYL 126
            ..:..|  |||||.:||::::||.|.|||||.||||||:||.|.|||:..:.....| |||....
  Fly   294 FFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGY-WPLGFTW 357

Human   127 CPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAI--MKIAIVWAISIGVSVPI 189
            |.::::.|||..::||:|:|.|||.||:.||||: .||..| ||.:  :||||||.:::.||..|
  Fly   358 CNIYVTCDVLACSSSILHMCFISLGRYMGIRNPL-GSRHRS-TKRLTGIKIAIVWVMAMMVSSSI 420

Human   190 PVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQA--------- 245
            .|:||.:|:.:......||:|:..|.:.||.|||:||:.:||.||.|||.:||::|
  Fly   421 TVLGLVNEKNIMPEPNICVINNRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPES 485

Human   246 ----------------------------------------------------------------- 245
                                                                             
  Fly   486 ELFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPA 550

Human   246 ---LM-----------------LLHG----------------------------HTEEPPGLSLD 262
               ||                 :::|                            |:...|..|
  Fly   551 ERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSPASS-- 613

Human   263 FLKCCKRNTAEEEN--------------------------SANP--------------------- 280
               |...:|:...:                          |::|
  Fly   614 ---CHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNV 675

Human   281 ----------------------------------------------NQDQ--------------- 284
                                                          ||.|
  Fly   676 GGNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPTA 740

Human   285 --------------------------NARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIM 323
                                      |.|....:.:|...:..|:..|:||:||||:|||.|::.
  Fly   741 LKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLC 805

Human   324 WCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYK 388
            |.||||.||:...|.: |  ::.|.::|..:|:|||.|.|||::||:||:.:|.||...|:||.|
  Fly   806 WSPFFILNIIFAACPE-C--QVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKCNCK 867

Human   389 VEKKP 393
            ...:|
  Fly   868 RSGRP 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR2C	NP_000859.2	7tmA_5-HT2C	54..385	CDD:341346	144/590 (24%)
		TM helix 1	55..81	CDD:341346	9/27 (33%)
		TM helix 2	88..114	CDD:341346	17/25 (68%)
		TM helix 3	127..157	CDD:341346	13/29 (45%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	151..153		0/1 (0%)
		TM helix 4	169..192	CDD:341346	11/24 (46%)
		TM helix 5	211..240	CDD:341346	15/28 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..301		8/160 (5%)
		TM helix 6	304..334	CDD:341346	18/29 (62%)
		TM helix 7	347..372	CDD:341346	12/24 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	364..368		2/3 (67%)
		PDZ-binding	456..458
5-HT2A	NP_730859.1	7tm_GPCRs	298..>473	CDD:475119	85/177 (48%)
		TM helix 2	321..343	CDD:410628	16/21 (76%)
		TM helix 3	359..381	CDD:410628	8/21 (38%)
		TM helix 4	404..420	CDD:410628	8/15 (53%)
		TM helix 5	443..466	CDD:410628	11/22 (50%)
		7tm_GPCRs	<779..858	CDD:475119	36/81 (44%)
		TM helix 6	792..814	CDD:410628	13/21 (62%)
		TM helix 7	826..851	CDD:410628	12/24 (50%)