Protein Alignment HTR2C and Octbeta3R

DIOPT Version :10

• Sequence 1: NP_000859.2
• Gene: HTR2C / 3358
• HGNCID: 5295
• Length: 458
• Species: Homo sapiens
• Sequence 2: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Alignment Length: 287
• Identity: 96/287 - (33%)
• Similarity: 142/287 - (49%)
• Gaps: 52/287 - (18%)

Human    53 QNWPALSIVI--------IIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPL 109
            ::|..||:::        ||:..:.||.|||::|...:||...||||::|||:|||||.|..|..
  Fly   131 ESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVITNYFVVSLAMADMLVALCAMTF 195

Human   110 SLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMK 174
            :....|....|....::|.|:.||||.||||||:|||.||:|||.||..|:|:....:.......
  Fly   196 NASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFM 260

Human   175 IAIVWAISIGVS-VPIPV-----------IGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPL 227
            :|.||.:...:| .||.:           |.|..::..||.|..       :.||.|.|:|:||.
  Fly   261 LANVWILPALISFTPIFLGWYTTEEHLREISLHPDQCSFVVNKA-------YALISSSVSFWIPG 318

Human   228 TIMVITYCLTIY---VLRRQAL------MLLH----GHTEEPPGLSLDFLKCCKRNTA---EEEN 276
            .:|::.| ..|:   :.:|:||      :||:    |||::|..||......|..|..   ||.:
  Fly   319 IVMLVMY-WRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPTSLSYLHPSDCDLNATSAREETH 382

Human   277 SA--------NPNQDQNARRRKKKERR 295
            ||        .|..|::..|.:..|.|
  Fly   383 SALSNLEDMLQPATDEDDDRDECDELR 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR2C	NP_000859.2	7tmA_5-HT2C	54..385	CDD:341346	96/286 (34%)
		TM helix 1	55..81	CDD:341346	11/33 (33%)
		TM helix 2	88..114	CDD:341346	14/25 (56%)
		TM helix 3	127..157	CDD:341346	21/29 (72%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	151..153		1/1 (100%)
		TM helix 4	169..192	CDD:341346	6/34 (18%)
		TM helix 5	211..240	CDD:341346	10/31 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..301		8/30 (27%)
		TM helix 6	304..334	CDD:341346
		TM helix 7	347..372	CDD:341346
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	364..368
		PDZ-binding	456..458
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	72/203 (35%)
		TM helix 1	142..167	CDD:320194	8/24 (33%)
		TM helix 2	174..200	CDD:320194	14/25 (56%)
		TM helix 3	213..243	CDD:320194	21/29 (72%)
		TM helix 4	255..278	CDD:320194	6/22 (27%)
		TM helix 5	302..331	CDD:320194	11/36 (31%)
		7tm_GPCRs	<1161..1234	CDD:475119
		TM helix 6	1167..1189	CDD:410628
		TM helix 7	1202..1227	CDD:410628