DRSC/TRiP Functional Genomics Resources

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Protein Alignment HTR2C and Dop2R

DIOPT Version :10

Sequence 1:NP_000859.2 Gene:HTR2C / 3358 HGNCID:5295 Length:458 Species:Homo sapiens
Sequence 2:NP_001014758.2 Gene:Dop2R / 33007 FlyBaseID:FBgn0053517 Length:905 Species:Drosophila melanogaster


Alignment Length:558 Identity:137/558 - (24%)
Similarity:211/558 - (37%) Gaps:224/558 - (40%)


- Green bases have known domain annotations that are detailed below.


Human    36 DIFNTSDG-GRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIAD 99
            :..|.:|. |..:..|  .|:.||.:::..|:|:.||||||::|..|:.|...||||::||||||
  Fly   359 ETLNLTDSCGELRVVD--HNYWALILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIAD 421

Human   100 MLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSR 164
            :||.::|||.::. .|.:..|.||..:|..:|::||:.||:||.:|.|||:|||:|:..||::::
  Fly   422 LLVAVVVMPFAVY-FLVNGAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAK 485

Human   165 FNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNT------TCVLNDPNFVLIGSFVAF 223
            ..:..:..:.|.:|||||..:..|| |:||        |||      .|...:.:|:|..|..:|
  Fly   486 HKNSRRVCLTILLVWAISAAIGSPI-VLGL--------NNTPNREPDVCAFYNADFILYSSLSSF 541

Human   224 FIPLTIMVITYCLTIYVLRRQA----------LMLLHG--------HTEEPPGLSLDFLKCCKR- 269
            :||..|||..|......||.:|          |..|.|        .|......:||..:...| 
  Fly   542 YIPCIIMVFLYWNIFKALRSRARKQRAARKPHLSELTGGSVIENIAQTRRLAETALDSSRHASRI 606

Human   270 -------NTA------EEENSANPNQDQ------------------------------------- 284
                   |||      |:||:.:|:.|.                                     
  Fly   607 LPDEAATNTASGSNEEEDENAISPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQLVV 671

Human   285 ----------------------------------------------------------------- 284
                                                                             
  Fly   672 ADPNGNHDSGYAASNVDDVLAGVAPASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQRRPT 736

Human   285 -----------------------------------------------------NARRRKKKERRP 296
                                                                 ::|:.||..:..
  Fly   737 GDDSPKRGEPALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQAS 801

Human   297 RGTMQAIN-------------NERKASKVLGIVFFVFLIMWCPFFITNILSVLC---EKSCNQKL 345
            |.|:..::             .||||:|.|.||..|||..|.|||..||:..:|   :|.|...|
  Fly   802 RFTIYKVHKASKKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPGL 866

Human   346 MEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYL 383
            ...::.  .|:||:.|.:||::||:||..:|:||...:
  Fly   867 TAYMMT--TWLGYINSFVNPVIYTIFNPEFRKAFKKIM 902

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HTR2CNP_000859.2 7tmA_5-HT2C 54..385 CDD:341346 133/539 (25%)
TM helix 1 55..81 CDD:341346 11/25 (44%)
TM helix 2 88..114 CDD:341346 15/25 (60%)
TM helix 3 127..157 CDD:341346 16/29 (55%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 151..153 1/1 (100%)
TM helix 4 169..192 CDD:341346 8/22 (36%)
TM helix 5 211..240 CDD:341346 10/28 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..301 9/181 (5%)
TM helix 6 304..334 CDD:341346 17/42 (40%)
TM helix 7 347..372 CDD:341346 8/24 (33%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 364..368 2/3 (67%)
PDZ-binding 456..458
Dop2RNP_001014758.2 7tmA_D2-like_dopamine_R 376..>565 CDD:320181 79/198 (40%)
TM helix 1 377..403 CDD:320181 11/25 (44%)
TM helix 2 410..436 CDD:320181 15/26 (58%)
TM helix 3 448..478 CDD:320181 16/29 (55%)
TM helix 4 490..513 CDD:320181 9/23 (39%)
TM helix 5 529..558 CDD:320181 10/28 (36%)
7tm_GPCRs <822..898 CDD:475119 32/77 (42%)
TM helix 6 828..850 CDD:320181 11/21 (52%)
TM helix 7 866..891 CDD:320181 9/26 (35%)
Blue background indicates that the domain is not in the aligned region.

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