Protein Alignment HTR2C and Htr2c

DIOPT Version :10

• Sequence 1: NP_000859.2
• Gene: HTR2C / 3358
• HGNCID: 5295
• Length: 458
• Species: Homo sapiens
• Sequence 2: NP_036897.2
• Gene: Htr2c / 25187
• RGDID: 2848
• Length: 460
• Species: Rattus norvegicus
• Alignment Length: 461
• Identity: 415/461 - (90%)
• Similarity: 431/461 - (93%)
• Gaps: 4/461 - (0%)

Human     1 MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGR-FKFPDGVQNWPALSIVIII 64
            ||||.|||.|.|:|||||||||.|||:|||||||||.||:||||| |:||||||||||||||:||
  Rat     1 MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVII 65

Human    65 IMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPV 129
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 IMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPV 130

Human   130 WISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGL 194
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 WISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGL 195

Human   195 RDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEP-PG 258
            |||.||||||||||||||||||||||||||||||||||||.|||||||||.||||.|||||. ..
  Rat   196 RDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELAN 260

Human   259 LSLDFLK-CCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLI 322
            :||:||. |||:|..||||:.|||.||.. ||||||:||||||||||||:|||||||||||||||
  Rat   261 MSLNFLNCCCKKNGGEEENAPNPNPDQKP-RRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLI 324

Human   323 MWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNY 387
            |||||||||||||||.|:||||||||||||||||||||||||||||||||||||||||.||||:|
  Rat   325 MWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDY 389

Human   388 KVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVS 452
            |.:|||||||||||||||||||||||||||||||.|..||:|.||||||||||||||||||:|||
  Rat   390 KPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVS 454

Human   453 ERISSV 458
            ||||||
  Rat   455 ERISSV 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR2C	NP_000859.2	7tmA_5-HT2C	54..385	CDD:341346	305/332 (92%)
		TM helix 1	55..81	CDD:341346	24/25 (96%)
		TM helix 2	88..114	CDD:341346	25/25 (100%)
		TM helix 3	127..157	CDD:341346	29/29 (100%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	151..153		1/1 (100%)
		TM helix 4	169..192	CDD:341346	22/22 (100%)
		TM helix 5	211..240	CDD:341346	27/28 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..301		19/26 (73%)
		TM helix 6	304..334	CDD:341346	28/29 (97%)
		TM helix 7	347..372	CDD:341346	24/24 (100%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	364..368		3/3 (100%)
		PDZ-binding	456..458		1/1 (100%)
Htr2c	NP_036897.2	7tmA_5-HT2C	55..387	CDD:341346	305/332 (92%)
		TM helix 1	56..82	CDD:341346	24/25 (96%)
		TM helix 2	89..115	CDD:341346	25/25 (100%)
		TM helix 3	128..158	CDD:341346	29/29 (100%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	152..154		1/1 (100%)
		TM helix 4	170..193	CDD:341346	22/22 (100%)
		TM helix 5	212..241	CDD:341346	27/28 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	276..301		18/25 (72%)
		TM helix 6	306..336	CDD:341346	28/29 (97%)
		TM helix 7	349..374	CDD:341346	24/24 (100%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	366..370		3/3 (100%)
		PDZ-binding	458..460		1/1 (100%)