Protein Alignment HTR2C and ser-1

DIOPT Version :10

• Sequence 1: NP_000859.2
• Gene: HTR2C / 3358
• HGNCID: 5295
• Length: 458
• Species: Homo sapiens
• Sequence 2: NP_001024728.1
• Gene: ser-1 / 181716
• WormBaseID: WBGene00004776
• Length: 683
• Species: Caenorhabditis elegans
• Alignment Length: 441
• Identity: 135/441 - (30%)
• Similarity: 210/441 - (47%)
• Gaps: 97/441 - (21%)

Human    14 HLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNW--PALSIVIIIIMTIGGNILVIM 76
            |.....||...:.:.|...|            :.| :||..:  |.|.::.:|     ||.||.:
 Worm    32 HFSTTSVWSIRVQLIPTMGI------------YHF-NGVALFLLPVLCLIGLI-----GNFLVCV 78

Human    77 AVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTAS 141
            |::.:::|||.|||||.|||:||:||..:|||||::..:...||.....:|.:::..||...:||
 Worm    79 AIATDRRLHNVTNYFLFSLALADLLVCCIVMPLSIVVEVRHGVWTWSVSMCLLYVYSDVFLCSAS 143

Human   142 IMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTT 206
            |:|:..||||||:.|..|: .:|..|:|...:||||||.:::.||.||.|:.:.|...:..|| .
 Worm   144 IVHMSVISLDRYLGISQPL-RTRNRSKTLIFIKIAIVWVVTLLVSCPIAVLAMHDTANILRNN-Q 206

Human   207 CVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALML----------------------- 248
            |::....:::.||.:.|.|||.||.:||..|..:|.:||.:|
 Worm   207 CMIFSRYYIIYGSTMTFLIPLCIMGVTYAKTTQLLNKQASILSQKAGDKFNGNGLRRTMPHRKLG 271

Human   249 --------------------LHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRR---- 289
                                .||.|..      .........||:...::.|:.:.|..::
 Worm   272 YARTYSATVNGTIANGKAIGAHGRTMS------SISNIANGETADRLGTSRPSINTNGHKQLQKA 330

Human   290 ----KKKERRP------------RGTMQA----INNERKASKVLGIVFFVFLIMWCPFFITNILS 334
                |.|.|..            |.::|.    :.||.||::||.:||..|.|.|.|||..|.|.
 Worm   331 STINKWKSRTSNLVTNFANKVGRRSSLQTATQDLANEHKATRVLAVVFACFFICWTPFFFINFLI 395

Human   335 VLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRC 385
            ....:  |.::.:.:.::|:|:|||.|.|||::||:|||.:|:||...|||
 Worm   396 GFGGE--NVQIPDWVASIFLWLGYVSSTINPIIYTVFNKRFRQAFVRILRC 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR2C	NP_000859.2	7tmA_5-HT2C	54..385	CDD:341346	125/399 (31%)
		TM helix 1	55..81	CDD:341346	8/27 (30%)
		TM helix 2	88..114	CDD:341346	17/25 (68%)
		TM helix 3	127..157	CDD:341346	13/29 (45%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	151..153		1/1 (100%)
		TM helix 4	169..192	CDD:341346	11/22 (50%)
		TM helix 5	211..240	CDD:341346	11/28 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..301		6/46 (13%)
		TM helix 6	304..334	CDD:341346	15/29 (52%)
		TM helix 7	347..372	CDD:341346	11/24 (46%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	364..368		2/3 (67%)
		PDZ-binding	456..458
ser-1	NP_001024728.1	7tmA_5-HT2	56..438	CDD:320180	124/396 (31%)
		TM helix 1	57..83	CDD:320180	9/30 (30%)
		TM helix 2	90..116	CDD:320180	17/25 (68%)
		TM helix 3	129..159	CDD:320180	13/29 (45%)
		TM helix 4	170..193	CDD:320180	11/22 (50%)
		TM helix 5	211..240	CDD:320180	11/28 (39%)
		TM helix 6	365..395	CDD:320180	15/29 (52%)
		TM helix 7	406..431	CDD:320180	11/24 (46%)