Protein Alignment HTR2C and htr2c

DIOPT Version :10

• Sequence 1: NP_000859.2
• Gene: HTR2C / 3358
• HGNCID: 5295
• Length: 458
• Species: Homo sapiens
• Sequence 2: XP_017951833.1
• Gene: htr2c / 100496012
• XenbaseID: XB-GENE-967634
• Length: 475
• Species: Xenopus tropicalis
• Alignment Length: 455
• Identity: 273/455 - (60%)
• Similarity: 338/455 - (74%)
• Gaps: 21/455 - (4%)

Human    17 GLLVWQSDISVS-----PVAAIVTDIFNTSDGGRFKFPD-GVQNWPALSIVIIIIMTIGGNILVI 75
            ||:.|..:.:|:     |.:|..    |.|:..:..... ..:||.||..:||||:|||||||||
 Frog    29 GLMAWHVNNNVTLNQSMPTSAPA----NASEEEKLSHESLADKNWSALLTLIIIILTIGGNILVI 89

Human    76 MAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTA 140
            ||||:||||.||||:||||||:||||||:||||:||:.|||||.|||||.|||:|||||||||||
 Frog    90 MAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLVTILYDYAWPLPRKLCPIWISLDVLFSTA 154

Human   141 SIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNT 205
            |||||||||||||||||||||||||||||||:||||.||.||||:|:|:|||||:|:.:||| |:
 Frog   155 SIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPVPVIGLQDDSRVFV-NS 218

Human   206 TCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRN 270
            :|||||.||||:||||||||||.|||.||||||.||::||.:.::   ||.|......:.|.|:.
 Frog   219 SCVLNDENFVLLGSFVAFFIPLIIMVFTYCLTIQVLQKQATVFMY---EEVPKQRRSSVNCLKKE 280

Human   271 TAEEENSANPNQDQ----NARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITN 331
            ...|..|...|.:.    |:...|:.....:||||:|||||:||||||||||:||||||||||||
 Frog   281 NNTENISMIQNHEAASHLNSPINKEGALFRKGTMQSINNERRASKVLGIVFFLFLIMWCPFFITN 345

Human   332 ILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVR 396
            |:||||:::|:.:||.:|||||||:|||.||||||||||||:.|||||::|:||.|...||..::
 Frog   346 IMSVLCKEACDNELMVELLNVFVWVGYVSSGINPLVYTLFNRTYRRAFASYIRCQYYNSKKTMLQ 410

Human   397 QIP---RVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV 458
            |..   ...:||:.|::||:|.||:.||.......:.|..||||....||.:|.|:|||||:|.|
 Frog   411 QNQCQHNATSTAMYGKDLNLNSYRNGNELTSVDMDETEEAIEMQPGISELSINNSNVVSERVSCV 475

Human   459  458
             Frog   476  475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR2C	NP_000859.2	7tmA_5-HT2C	54..385	CDD:341346	233/334 (70%)
		TM helix 1	55..81	CDD:341346	20/25 (80%)
		TM helix 2	88..114	CDD:341346	20/25 (80%)
		TM helix 3	127..157	CDD:341346	28/29 (97%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	151..153		1/1 (100%)
		TM helix 4	169..192	CDD:341346	16/22 (73%)
		TM helix 5	211..240	CDD:341346	24/28 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..301		7/30 (23%)
		TM helix 6	304..334	CDD:341346	27/29 (93%)
		TM helix 7	347..372	CDD:341346	20/24 (83%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	364..368		3/3 (100%)
		PDZ-binding	456..458		1/1 (100%)
htr2c	XP_017951833.1	7tmA_5-HT2C	68..399	CDD:341346	233/334 (70%)
		TM helix 1	69..95	CDD:341346	20/25 (80%)
		TM helix 2	102..128	CDD:341346	20/25 (80%)
		TM helix 3	141..171	CDD:341346	28/29 (97%)
		TM helix 4	183..206	CDD:341346	16/22 (73%)
		TM helix 5	224..253	CDD:341346	24/28 (86%)
		TM helix 6	318..348	CDD:341346	27/29 (93%)
		TM helix 7	361..386	CDD:341346	20/24 (83%)