Protein Alignment Spindly and SPDL1

DIOPT Version :9

• Sequence 1: NP_608791.2
• Gene: Spindly / 33578
• FlyBaseID: FBgn0031549
• Length: 781
• Species: Drosophila melanogaster
• Sequence 2: NP_001316568.1
• Gene: SPDL1 / 54908
• HGNCID: 26010
• Length: 622
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 137/602 - (22%)
• Similarity: 249/602 - (41%)
• Gaps: 163/602 - (27%)

  Fly    31 DQSEKDAQRIYELKRNLDTALAAESYLTQE-----LEHLSSQPVAIASGGNGQELEELRRKFKTL 90
            :|.:...||..|||..:..:|:.|....::     ||.|..|    .|..:|||:.||:.|.:.|
Human    56 EQEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQ----LSRSHGQEVNELKTKIEKL 116

  Fly    91 KEEQDVLQQDYDAKVEETRSLKDKLTAAEKNLAEKSAS---RSNQLHDDFFARLNALELENCELL 152
            |.|.|      :|::.| :.||.::...::.|:.||..   .|.::.:...:.:.||::|
Human   117 KVELD------EARLSE-KQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIE----- 169

  Fly   153 QKLAEYEDLRIANTLAVAEKEKTIECLQDRVSCMEQNLNCKRDELEEK----------------- 200
              |.|.|.::    ..:.|:...::..|:::..:..||..:.|.|:|:
Human   170 --LTEMESMK----TTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEK 228

  Fly   201 -------LQL-LESCQEQLVDANAKIALLTSAPENNDRKGNSLFAEVDDQRQAMKQILAAQKKSY 257
                   ||: |:...:|.:|.|:              |||||||||:|:|.||::.|.:.|..|
Human   229 ARVANQDLQVQLDQALQQALDPNS--------------KGNSLFAEVEDRRAAMERQLISMKVKY 279

  Fly   258 LDMKKIFTDSQFEIRRLKRENVAMHTELQACSTIFCSADK--TYQNKLNERIRQLMTANDSLERQ 320
            ..:||....::.:::|:|.: :|...:::...|.|...::  ....:.|..|:.|:....:||:.
Human   280 QSLKKQNVFNREQMQRMKLQ-IATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKF 343

  Fly   321 LNL--SQERLRQLAS---EKSVTWLDSM---LDFCKRETDELKAQLHSMRIQKAGLEERMRCVQQ 377
            .||  |.|....:.|   |.:..:.|.:   ||...:|.:..|.:|...|::  .|.|..|.:..
Human   344 KNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMK--ALFESQRALDI 406

  Fly   378 EMARWRFESLKSRCV-LIDRENL-----LAEHKIVFKPMQAMEFNIKEAELKTALPRIVSVAAQS 436
            |...:..|    ||: |.:.||:     |.|.|:.::|.:.:|..:
Human   407 ERKLFANE----RCLQLSESENMKLRAKLDELKLKYEPEETVEVPV------------------- 448

  Fly   437 PSSSAQLHTHPETSLKSAAETTSKSFPTATEIIVLDAPL------KPAIKEEVVEPLSQELKPAL 495
                          ||...|.......||.:..|.::.|      .|..|||     :|....:|
Human   449 --------------LKKRREVLPVDITTAKDACVNNSALGGEVYRLPPQKEE-----TQSCPNSL 494

  Fly   496 KDTSVKVEQELEVSESKACIKRTPIKTIMGMKIKREIDLNLEQQDAVDIKKELEAPELIPKPQLK 560
            :|.::::|:.:.:        .||:.::...|     :|.::.|    :|||.:..:||
Human   495 EDNNLQLEKSVSI--------YTPVVSLSPHK-----NLPVDMQ----LKKEKKCVKLI------ 536

  Fly   561 GTPVKA----KNDGVTP 573
            |.|..|    :..|.||
Human   537 GVPADAEALSERSGNTP 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spindly	NP_608791.2	Smc	<11..336	CDD:224117	84/344 (24%)
SPDL1	NP_001316568.1	GrpE	351..>417	CDD:295646	16/71 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I9050
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	76	1.000	Inparanoid score	I5266
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	3.010