DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spindly and Spdl1

DIOPT Version :9

Sequence 1:	NP_608791.2	Gene:	Spindly / 33578	FlyBaseID:	FBgn0031549	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_001029310.1	Gene:	Spdl1 / 303037	RGDID:	1306908	Length:	597	Species:	Rattus norvegicus

Alignment Length:	593	Identity:	144/593 - (24%)
Similarity:	240/593 - (40%)	Gaps:	118/593 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 HQQLKDQSEKDAQRIYELKRNLDTALAAESYLTQELEHLSSQPVAIAS-------GGNGQELEEL 83
            |:::...:|...|..|.|:|.::........|:.|.|.|..|..|...       ..:.||:..|
  Rat    44 HEEMMTTAENYNQEKYALQREVELKSRMLESLSCECEALRQQQKAQLEQLEMQLHRSHRQEVHGL 108

  Fly    84 RRKFKTLKEEQDVLQQDYDAKVEETRSLKDKLTAAEKNLAEKSASRSNQLHDDFFARLNALELEN 148
            |.|.:.||.|.|      :|::.| :.||.||....:.|:.|    |.:|.  ..:...||...:
  Rat   109 RNKLENLKVELD------EARLSE-KQLKQKLDHQGELLSHK----SEELR--LLSEQRALSSVS 160

  Fly   149 CELLQ---KLAEYEDLRIANTLAVAEKEKTIECLQDRVSCMEQNLNCKRDELEEKLQ-------- 202
            .|||.   :|.|.|.::    .|:.|:...::|.|:::.|:..:|..:.|.|:|:.:
  Rat   161 SELLSLQTELTEAEGVK----NALREEVNELQCKQEQLECLNASLLHQVDRLKEEKEEREKEAVS 221

  Fly   203 ---LLESCQEQLVDANAKI--ALLTSAPENNDRKGNSLFAEVDDQRQAMKQILAAQKKSYLDMKK 262
               .||..:.:..|...::  ||..:|..|:  |||||||||:|:|.||::.|...|..|..:||
  Rat   222 YYNALEKARVENQDLQVQLGHALQQAADPNS--KGNSLFAEVEDRRVAMERRLNLMKDKYQSLKK 284

  Fly   263 --IFTDSQFEIRRLKRENV----AMHTELQACSTIFCSADKTYQNKLNERIRQLMTANDSLERQL 321
              .||..|....:|:...:    ...||.:....:|...::.     |..|:.|:...:.||:..
  Rat   285 QNAFTRDQMNKMKLQISTLLRMRGSQTEFEQQERLFAMLEQK-----NGEIKHLLGEINKLEKFK 344

  Fly   322 NLSQERLRQLAS--------EKSVTWLDSM---LDFCKRETDELKAQLHSMRIQKAGLEERMRCV 375
            || .|.:...:|        |.|..:.|.:   ||...:|.:..|.:|...|::  .|.|..|.:
  Rat   345 NL-YENMESKSSTSDSACALEDSTYYTDLLQLKLDKLNKENESTKGELSIQRMK--ALFESQRTL 406

  Fly   376 QQEMARWRFESLKSRCVLIDRENL-----LAEHKIVFKPMQAMEFNIKEAELKTALPRIVSVAAQ 435
            ..|...:..|   ....|.:.|||     |.|.|:.::|.:.:|..:.:.. :..||..::...:
  Rat   407 DIERKLFANE---RHLQLSESENLKLRAKLDELKLKYEPEERIEVPVLKRR-REVLPLNINTPEE 467

  Fly   436 SPSSSA--------QLHTHPETSLKSAAETT-----------SKSFPTATEIIVLDAPLKPAIKE 481
            :.::||        .|....|:.|.:..:.|           .||.|..|:      |.|.....
  Rat   468 TAAASATGEDVSRLPLERKEESCLDNLKDNTVQWKQPASLSPHKSLPLDTQ------PKKEKCVT 526

  Fly   482 EVVEPLSQEL----------KPALKD-----TSVKVEQELEVSESKACIKRTPIKTIMGMKIKRE 531
            .|..|.|.|:          .|.|.:     |.||..:|......|...|::  .|||.:..|..
  Rat   527 LVASPASTEVLHEQSGNTPSSPRLTEESRLPTKVKERKEATSKLEKGASKKS--HTIMYVSSKST 589

  Fly   532 IDLNLEQQ 539
            .::...||
  Rat   590 PEMQCPQQ 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spindly	NP_608791.2	Smc	<11..336	CDD:224117	90/346 (26%)
Spdl1	NP_001029310.1	DUF342	<265..351	CDD:302792	23/91 (25%)
Spdl1	NP_001029310.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..597		15/67 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	2	1.960