Protein Alignment CG8852 and pan-1

DIOPT Version :10

• Sequence 1: NP_608790.2
• Gene: CG8852 / 33577
• FlyBaseID: FBgn0031548
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: NP_497925.1
• Gene: pan-1 / 175596
• WormBaseID: WBGene00003915
• Length: 594
• Species: Caenorhabditis elegans
• Alignment Length: 535
• Identity: 116/535 - (21%)
• Similarity: 195/535 - (36%)
• Gaps: 139/535 - (25%)

  Fly   118 DNCVDLESVEIQRF-VGDATLKLSCGGALIPNLTAVSFRYNELG--TLSGETIQDL-PHLKILHL 178
            :|...|...|:.|. :.|:|:.: ....|..|:.|...:....|  ||...:.|.| ...::|.|
 Worm    71 ENLASLNGTELGRLTIRDSTVNV-LPQDLFENVFAKQVKLERCGLSTLQPNSFQSLGGSAELLSL 134

  Fly   179 QQNSLRYLE--YFKEHSDLEELLIQDERDLVLRFNEILNQLPELRRLSLRNVEKIEDQFLRILPE 241
            ::|.::.||  .|.....|:.|      ||.      :|::.|:...:...::|:|:..|
 Worm   135 RENRIKKLEKGLFTGLKSLKTL------DLA------MNKIQEIDVGAFEELKKVEELLL----- 182

  Fly   242 NLTDLIIENTPIQPGVLYLTEGVAKLVNVTITNCQL----KGFALQPAHNLDIMYLNLSGNAISS 302
            |..|:.:    ::.|..   :|:..|..:|:.||.|    || |.:..::|:  .|.||.|.:.:
 Worm   183 NENDIRV----LKTGTF---DGMKNLKKLTLQNCNLEIIQKG-AFRGLNSLE--QLILSNNNLEN 237

  Fly   303 LNISFESGPSTLLTLDLSRNRLEHLNFTWFYRTTSLRSLHLQENHFHSLSLFQLGFISSASIHHI 367
            ::.:..|....|..|||..|::.::....|   ..|..|.|..|...|:...:|..:.|..:...
 Worm   238 IDWTIFSALKNLRVLDLGSNKISNVEMKSF---PKLEKLVLNNNTIDSMKSIKLKDLPSLVVALF 299

  Fly   368 DLRSNELMSFRDTENADLPSWNPQLRISIDDNPWSCQWMLNFSHMQPQLFR--------LFQYSK 424
            |  .|::.|..|.:...|...:....:|:..|        |.|.:.|:.|:        |.||::
 Worm   300 D--RNKIESIGDMDMFGLTRSDRIETLSLARN--------NLSQISPKAFQHTPNLITLLLQYNQ 354

  Fly   425 YISHININGLSCTPQEPPSEEPPKVRRIMHVRINGTDSSIPVPHPHGNVSSFTVLYGNPVELHRS 489
            .             :|..|..|.:||                       :.|.......|.|..|
 Worm   355 I-------------EELSSHSPSQVR-----------------------TPFLASLKKLVTLQLS 383

  Fly   490 QRSLALIIVFMLPLGIAFLFL-----------------LLYLYLHCERLFHLSYYASGLPCFGGE 537
            ..:|::|....||..::.|.|                 :..||||..:|.:|         :.|.
 Worm   384 SNNLSVIRSDELPKSLSSLALDHNVISKIEARALEGMEIKRLYLHSNKLNYL---------YQGT 439

  Fly   538 KSSSGPRFVDHVDIVRYP---IANGGSSCPVDVETELP----DGYETPVSGGTSIC----NCTGH 591
            ..|..|:.|:.||:...|   :.|       |.:..||    ...|..|:.|...|    ||...
 Worm   440 FDSFSPKSVEAVDVSLNPWVCVCN-------DPKEWLPRWLEASEEADVAEGALGCLAIPNCGQK 497

  Fly   592 RESTCSRTHHVTYES 606
            ..||........|.|
 Worm   498 EGSTVMPEEEEVYRS 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8852	NP_608790.2	LRR	<122..452	CDD:443914	78/347 (22%)
		leucine-rich repeat	149..172	CDD:275380	6/25 (24%)
		leucine-rich repeat	173..194	CDD:275380	6/22 (27%)
		leucine-rich repeat	220..242	CDD:275380	3/21 (14%)
		leucine-rich repeat	243..266	CDD:275380	3/22 (14%)
		leucine-rich repeat	267..287	CDD:275380	8/23 (35%)
		leucine-rich repeat	288..313	CDD:275380	6/24 (25%)
		leucine-rich repeat	314..337	CDD:275380	6/22 (27%)
		leucine-rich repeat	364..387	CDD:275378	5/22 (23%)
		leucine-rich repeat	392..403	CDD:275378	2/10 (20%)
pan-1	NP_497925.1	leucine-rich repeat	81..104	CDD:275380	5/23 (22%)
		leucine-rich repeat	105..128	CDD:275380	5/22 (23%)
		leucine-rich repeat	130..152	CDD:275380	6/21 (29%)
		LRR_8	132..187	CDD:404697	16/71 (23%)
		leucine-rich repeat	153..176	CDD:275380	6/34 (18%)
		LRR	163..>418	CDD:443914	64/318 (20%)
		leucine-rich repeat	177..200	CDD:275380	6/34 (18%)
		leucine-rich repeat	201..224	CDD:275380	8/23 (35%)
		leucine-rich repeat	225..248	CDD:275380	6/24 (25%)
		leucine-rich repeat	249..269	CDD:275380	6/22 (27%)
		leucine-rich repeat	270..293	CDD:275380	6/22 (27%)
		leucine-rich repeat	294..320	CDD:275380	5/27 (19%)
		leucine-rich repeat	321..344	CDD:275380	6/30 (20%)
		leucine-rich repeat	377..398	CDD:275380	7/20 (35%)
		leucine-rich repeat	399..420	CDD:275380	2/20 (10%)
		leucine-rich repeat	423..442	CDD:275380	7/27 (26%)