Protein Alignment CG8852 and lingo1

DIOPT Version :10

• Sequence 1: NP_608790.2
• Gene: CG8852 / 33577
• FlyBaseID: FBgn0031548
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: NP_001093719.1
• Gene: lingo1 / 100101739
• XenbaseID: XB-GENE-921957
• Length: 606
• Species: Xenopus tropicalis
• Alignment Length: 622
• Identity: 137/622 - (22%)
• Similarity: 219/622 - (35%)
• Gaps: 209/622 - (33%)

  Fly    44 PAC------VIRATLYKTSSSERSQNDFGLPLAIDCS-----------------ENSSMGMNYFD 85
            |:|      ::..::...|:|       |.|...|||                 |.........|
 Frog     6 PSCLCPILLIVVGSILSGSAS-------GCPQRCDCSPQDRSVLCHRKRYLDVPEGIPTDTRLLD 63

  Fly    86 LGAQRVAGKRHVSLDGFQTPPLGISSY--GLEYLDNCVDLESVEIQRFVGDATLKLSCG-----G 143
            |...|:   :.::.|.|...|     |  .||..:|.|.:  :|...|.|...|: |.|     .
 Frog    64 LSKNRI---KALNQDEFSAFP-----YLEELELNENIVSI--IEPGAFNGLFNLR-SLGLRSNRL 117

  Fly   144 ALIP--------NLTAVSFRYNELGTLSGETIQDLPHLKILHLQQNSLRYLEY--FKEHSDLEEL 198
            .|||        |||.:....|::..|..:..|||.:||.|.:..|.|.|:.:  |:..:.||||
 Frog   118 KLIPLGVFTGLSNLTQLDISENKIVILLDDMFQDLYNLKSLEVGDNDLVYISHRAFRGLNSLEEL 182

  Fly   199 LIQDERDLVLRFNEILNQLPELRRLSLR--NVEKIED-QFLRILPENLTDLIIENTPIQPGVLYL 260
            .: ::.:|.....|.|:.|..|..|.||  |:..|.| .|.|:.  .|.:|.|.:.|      ||
 Frog   183 TL-EKCNLTSVPTEALSHLHGLITLKLRYLNINVIRDYSFKRLY--RLKNLEIAHWP------YL 238

  Fly   261 TEGVAKLVNVTITNCQLKGFALQPAHNLDIMYLNLSGNAISSLNISFESGPST-------LLTLD 318
            .         |:|:..|.|             |||:..:|:..|:|  |.|..       |..|:
 Frog   239 D---------TMTSNGLYG-------------LNLTSLSITHSNLS--SIPYVAIRHLVYLRFLN 279

  Fly   319 LSRNRLEHLNFTWFYRTTSLRSLHLQENHFHSLSLFQLGFISSASIHHID---LRSNELMSFRDT 380
            ||.|.:..:..:..|....|:..||.......:..:....::...:.::.   |.:.|..||...
 Frog   280 LSYNPITAVEGSMLYELLRLQEFHLVGGQLSVVEPYAFRGLNHLKVLNVSSNYLSTLEESSFHSV 344

  Fly   381 ENADLPSWNPQLRISIDDNPWSC----------QWMLNFSH----------------------MQ 413
            .|.:        .:.:|.||.:|          :|.||||.                      :|
 Frog   345 GNLE--------TLILDKNPLACDCRLLWIFRRRWRLNFSRQQPSCSSPEYVQGKEFKDFPDVLQ 401

  Fly   414 PQLF-----RLFQYSKYISHIN----INGLSCTPQEPPS----EEPPKV---------------- 449
            |..|     |:..:|..:.:::    ::.......:||.    :.|.|.
 Frog   402 PNYFTCRRARIQDHSAQVVYVDEGHTVHFFCRADGDPPPTILWQSPRKTFITSKSNGRLTVFPDG 466

  Fly   450 ---RRIMHVRINGT-----------DSSIPVPH--------PHGNVSSFTVLYGNPVE--LHRSQ 490
               .|...|:.|||           |:|:...|        ||....:|..:...|.|  ::.::
 Frog   467 TLEVRYAQVQDNGTYHCIASNAGGNDTSLAHLHVRSYSPNWPHKPNKTFAFMSNQPNESDVNSTR 531

  Fly   491 RSL-------ALIIV----FMLPLGIAFLFLLLYLYL 516
            .|:       .|||.    |:..||:. ||.|:.|:|
 Frog   532 ASVPFPFDIKTLIIATTMGFISFLGVV-LFCLVLLFL 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8852	NP_608790.2	LRR	<122..452	CDD:443914	91/421 (22%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..194	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..242	CDD:275380	9/24 (38%)
		leucine-rich repeat	243..266	CDD:275380	6/22 (27%)
		leucine-rich repeat	267..287	CDD:275380	4/19 (21%)
		leucine-rich repeat	288..313	CDD:275380	8/24 (33%)
		leucine-rich repeat	314..337	CDD:275380	6/22 (27%)
		leucine-rich repeat	364..387	CDD:275378	5/25 (20%)
		leucine-rich repeat	392..403	CDD:275378	3/10 (30%)
lingo1	NP_001093719.1	LRRNT	27..61	CDD:214470	6/33 (18%)
		LRR 1	58..79		5/23 (22%)
		leucine-rich repeat	59..82	CDD:275380	6/30 (20%)
		LRR	61..358	CDD:443914	87/348 (25%)
		LRR 2	82..103		7/22 (32%)
		leucine-rich repeat	83..106	CDD:275380	7/24 (29%)
		LRR 3	106..127		6/21 (29%)
		leucine-rich repeat	107..130	CDD:275380	6/23 (26%)
		LRR 4	130..151		5/20 (25%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		LRR 5	154..175		7/20 (35%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		LRR 6	178..199		7/21 (33%)
		leucine-rich repeat	179..250	CDD:275380	27/101 (27%)
		LRR 7	202..223		8/20 (40%)
		leucine-rich repeat	203..226	CDD:275380	9/24 (38%)
		LRR 8	250..271		7/22 (32%)
		leucine-rich repeat	251..274	CDD:275380	6/24 (25%)
		LRR 9	274..295		5/20 (25%)
		leucine-rich repeat	275..298	CDD:275380	6/22 (27%)
		LRR 10	298..319		3/20 (15%)
		leucine-rich repeat	299..322	CDD:275380	3/22 (14%)
		LRR 11	322..343		4/20 (20%)
		leucine-rich repeat	323..343	CDD:275380	4/19 (21%)
		PCC	327..>407	CDD:188093	17/87 (20%)
		Ig	409..500	CDD:472250	13/90 (14%)
		Ig strand B	428..432	CDD:409353	0/3 (0%)
		Ig strand C	441..445	CDD:409353	0/3 (0%)
		Ig strand E	466..470	CDD:409353	0/3 (0%)
		Ig strand F	480..485	CDD:409353	1/4 (25%)
		Ig strand G	493..496	CDD:409353	1/2 (50%)