DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sr-CIV and mamdc2b

DIOPT Version :9

Sequence 1:	NP_608789.1	Gene:	Sr-CIV / 33576	FlyBaseID:	FBgn0031547	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	XP_017213507.1	Gene:	mamdc2b / 798369	ZFINID:	ZDB-GENE-091117-16	Length:	698	Species:	Danio rerio

Alignment Length:	244	Identity:	70/244 - (28%)
Similarity:	109/244 - (44%)	Gaps:	54/244 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 EQIQNGFV-----LNAPMKAKII----CSD--GHGLVGNRIAYCDGEKWSTQLGSCALRRQT--- 127
            |:|:|.::     :.:..||:::    |.|  ..|.||     .|..|.:.  |.|:|...:
Zfish   454 EKIRNVWIAVELTIQSEKKAQVVFISTCKDIWSCGSVG-----LDDIKVTP--GDCSLLAASSLL 511

  Fly   128 IDVSCDFESEDMCGWTAE-LSFLGTW--KRVSTVADFHSEKTGPQKDHTFQNQSIGHYVRMETES 189
            :...||||| .:||::.: :...|.|  .|..|...:    |||..|||   ..:|||:.:|...
Zfish   512 LPSHCDFES-GLCGFSQDKVGDSGDWYLARGPTPTSY----TGPGGDHT---TGLGHYMHIEASV 568

  Fly   190 DAFG-TYHFLSPLYPKELSLSGA----CFQFHYFMFGSGVGSLLVSIKPVSVTIGDIFKTNHPYK 249
            ...| ....||.      :|.|.    |.||:|.|:|||:|.|.|.::........:..|:|
Zfish   569 MLAGHKARLLSS------TLRGTRETQCLQFYYHMYGSGIGQLSVYLQTGQENDDRLLWTSH--- 624

  Fly   250 FDQFVMTGSQGARWLEHTIDINKMDEDFQVIFTATDARSQYGDIAIDDV 298
                   |.||..||..:::.: .|:..|::|.||...|...|||:||:
Zfish   625 -------GEQGISWLRASLNYH-YDQQHQIVFEATRGASVRSDIAVDDI 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sr-CIV	NP_608789.1	MAM	132..306	CDD:279023	55/175 (31%)
		MAM	132..301	CDD:99706	55/175 (31%)
		Somatomedin_B	336..376	CDD:279385
mamdc2b	XP_017213507.1	MAM	41..175	CDD:279023
		MAM	41..175	CDD:99706
		MAM	178..334	CDD:279023
		MAM	178..334	CDD:99706
		MAM	349..502	CDD:279023	13/54 (24%)
		MAM	349..502	CDD:99706	13/54 (24%)
		MAM	516..674	CDD:279023	55/175 (31%)
		MAM	516..672	CDD:99706	55/175 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9895
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7243
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910