DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sr-CIV and si:ch211-106h4.4

DIOPT Version :9

Sequence 1:	NP_608789.1	Gene:	Sr-CIV / 33576	FlyBaseID:	FBgn0031547	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	XP_017207311.2	Gene:	si:ch211-106h4.4 / 559790	ZFINID:	ZDB-GENE-070705-14	Length:	2402	Species:	Danio rerio

Alignment Length:	423	Identity:	97/423 - (22%)
Similarity:	152/423 - (35%)	Gaps:	120/423 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AIVLISSVDRTNARC--LESVHLEHGSTEIVN---GSIIFHCD---------------QGYFL-- 48
            :.||:..|......|  ..|...|.|:...||   |....|.|               .|.||
Zfish  1030 SFVLLDDVSVKTGACSPAGSCDFESGTCTWVNVADGHDWIHADGHFRRPLVDYTTHSADGKFLLS 1094

  Fly    49 --QGSKVFTCDRGIPRGKKPFCAKSGCQEYEQIQNGFVLNAPMKAKIICSDGHG----LVGNRIA 107
              |.:|.....|.:...::...:...|.|:....||   :.|...|::...|..    |...|::
Zfish  1095 PSQRNKQGHTGRSVLISERIQSSSDSCFEFWCYMNG---SDPGILKVLLDSGSTEQELLFETRVS 1156

  Fly   108 YCDGEKW--------STQLGSCALRRQT-------ID-------------------VSCDFESED 138
               |..|        .|:.....:..||       :|                   :.||||: |
Zfish  1157 ---GNDWKNVSITVDETRPFQIQIEAQTGSDGFIAVDDFRLTNGPCKDIGVESGEFIGCDFET-D 1217

  Fly   139 MCGWTAELSFLG--TWKR---VSTVADFHSEKTGPQKDHTFQNQSIGHYVRMETESDAFGTYHFL 198
            .|.|| ::| :|  .|:|   .:|.|:     |||..||| ....:|.|:.:|.......:|..|
Zfish  1218 SCDWT-DIS-VGQFVWERDQNGTTTAN-----TGPSVDHT-TGTELGWYMAVEASHGDQNSYAAL 1274

  Fly   199 SPLYPKELSLSGACFQFHYFMFGSGVGSLLVSIKPVSVTIGDIFKTNHPYKFDQFVMTGSQGARW 263
            .....||.| :....:|:|.|||.|:|.:            .:|....|.:...:.|:|:.|..|
Zfish  1275 QSPAMKEAS-NECLLEFYYHMFGEGIGEI------------KVFLQEGPRRTPLWWMSGNHGDEW 1326

  Fly   264 LEHTIDINKMDEDFQVIFTATDARSQYGDIAIDDVKLMAAKECARRSTFIEEPKKPIEESDITDS 328
            ....:.:.:..:.|.::|.|:...|:.|||||||:..:   .|.     :.||.:|.:|...|
Zfish  1327 RRAELSVGRTHQVFTLLFEASRTYSELGDIAIDDIAFL---NCT-----VPEPHEPCQEGTFT-- 1381

  Fly   329 LGYQMTDCSGR-CGQDFVRGRYINEGCRCQESC 360
                   ||.. |.:       :|..|...:.|
Zfish  1382 -------CSNHVCVE-------LNRVCDYSDDC 1400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sr-CIV	NP_608789.1	MAM	132..306	CDD:279023	52/178 (29%)
		MAM	132..301	CDD:99706	52/173 (30%)
		Somatomedin_B	336..376	CDD:279385	6/26 (23%)
si:ch211-106h4.4	XP_017207311.2	LDLa	18..53	CDD:238060
		MAM	56..210	CDD:332481
		MAM	223..378	CDD:99706
		MAM	384..545	CDD:99706
		MAM	551..708	CDD:99706
		MAM	732..888	CDD:99706
		MAM	894..1045	CDD:306977	3/14 (21%)
		MAM	1050..1199	CDD:99706	28/154 (18%)
		MAM	1212..1365	CDD:99706	52/177 (29%)
		LDLa	1375..1409	CDD:238060	8/42 (19%)
		MAM	1418..1571	CDD:332481
		LDLa	1609..1646	CDD:238060
		MAM	1645..1804	CDD:332481
		MAM	1818..1974	CDD:99706
		MAM	1981..2138	CDD:99706
		MAM	2144..2306	CDD:99706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9895
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006092
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.000