DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sr-CIV and Sr-CII

DIOPT Version :9

Sequence 1:	NP_608789.1	Gene:	Sr-CIV / 33576	FlyBaseID:	FBgn0031547	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_001188908.1	Gene:	Sr-CII / 44219	FlyBaseID:	FBgn0020377	Length:	599	Species:	Drosophila melanogaster

Alignment Length:	417	Identity:	202/417 - (48%)
Similarity:	270/417 - (64%)	Gaps:	35/417 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLWAIVLISSVDRTNARCLESVHLEHGS--TEIVNGSIIFHCDQGYFLQGSKVFTCDR-GIPRGK 64
            |...::|..|:|..|..|..|:.||:|.  |. .|..:||.|::|:.|||:.:.|||| |..|.|
  Fly     5 LALTLILAYSLDTANGSCEGSLDLENGRFFTR-SNNLVIFQCNRGFVLQGNSIHTCDRDGRLREK 68

  Fly    65 KPFCAKSGCQEYEQIQNGFVLNAPMKAKIICSDGHGLVGNRIAYCDGEKWSTQLGSCALRRQTID 129
            |||||:.||.:.|...||:||:.|:||:|:|.||..|.|:|.|:|||||||||||:|.....|:|
  Fly    69 KPFCARKGCDKPEDPTNGYVLDNPVKAEIVCLDGFVLYGSRTAFCDGEKWSTQLGACRRSNHTMD 133

  Fly   130 VSCDFESEDMCGWTAELSFLGTWKRVSTVADFHSEKTGPQKDHTFQNQSIGHYVRMETESDAFGT 194
            .||||||||.|||:||.:....|||:|.|.|||..:|||:.||||.|.|.|||:||||:.:|:|:
  Fly   134 HSCDFESEDQCGWSAEETIWLPWKRISAVTDFHHPRTGPRYDHTFGNTSGGHYMRMETQIEAYGS 198

  Fly   195 YHFLSPLYPKELSLSGA-CFQFHYFMFGSGVGSLLVSIKPVSVTIGDI---FKTNHPYKFDQFVM 255
            |||:||:||:.|.|:.| ||:|||||||:||..|::|:||.|:.|.|:   |::|.    .:|.:
  Fly   199 YHFVSPVYPRSLCLNVACCFRFHYFMFGAGVDRLVLSVKPASLQIDDMWNSFRSNS----SKFEI 259

  Fly   256 TGSQGARWLEHTIDINKMDEDFQVIFTATDARSQYGDIAIDDVKLMAAKECA----RRSTFIEEP 316
            |||||..|||:||.|:||.|||||:|||||||||:|||||||||||...||.    ..:|..|..
  Fly   260 TGSQGTHWLENTITIDKMHEDFQVVFTATDARSQFGDIAIDDVKLMTGSECGVDGYSTTTTTESA 324

  Fly   317 KKPIEESDITDSLGYQMTDCSGRCGQDFVRGR--YINEG----CRCQESCLVNGNCCLNYVKECH 375
            ...:..|:  :.|.:.|..|:.||| ....|.  :.:||    |.|.:||::|.|||.||.::|.
  Fly   325 SSAMSSSE--EPLVFDMMSCTFRCG-SISPGSPLFSDEGIVMSCGCDDSCILNNNCCPNYFEKCV 386

  Fly   376 KDLVIAPYNELKFWRLWNLWSGDSNVT 402
            |:|.|..          |::...:|.|
  Fly   387 KELDIGS----------NVFLNSANTT 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sr-CIV	NP_608789.1	MAM	132..306	CDD:279023	107/177 (60%)
		MAM	132..301	CDD:99706	105/172 (61%)
		Somatomedin_B	336..376	CDD:279385	18/45 (40%)
Sr-CII	NP_001188908.1	CCP	22..72	CDD:153056	23/50 (46%)
		CCP	77..125	CDD:214478	28/47 (60%)
		MAM	136..312	CDD:279023	109/179 (61%)
		MAM	136..308	CDD:99706	107/175 (61%)
		Somatomedin_B	341..387	CDD:279385	18/46 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470079
Domainoid	1	1.000	66	1.000	Domainoid score	I9895
eggNOG	1	0.900	-	-		E1_2CMY0
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I5116
Isobase	1	0.950	-	0	Normalized mean entropy	S8224
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006092
OrthoInspector	1	1.000	-	-		mtm9576
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23282
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7243
	10	9.840