DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sr-CIV and Mamdc4

DIOPT Version :9

Sequence 1:	NP_608789.1	Gene:	Sr-CIV / 33576	FlyBaseID:	FBgn0031547	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_001074668.2	Gene:	Mamdc4 / 381352	MGIID:	2685841	Length:	1232	Species:	Mus musculus

Alignment Length:	312	Identity:	73/312 - (23%)
Similarity:	122/312 - (39%)	Gaps:	64/312 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 APMKA--KIICSDGHGLVGNRIAYCDGEKWSTQLG-SCALRRQTIDVSCDFESEDMCGWTAELSF 148
            :|:||  ..:|..|.         |..|   ||.| ..|....:...:|:|| :|.||| .::|.
Mouse    35 SPIKAVCNFVCDCGD---------CSDE---TQCGFHGASTIPSTSFTCNFE-QDSCGW-QDIST 85

  Fly   149 LG-TWKRVSTVADFHSEKTGPQKDHTFQNQSIGHYVRMETESDAF-GTYHFLSPLYPKELSLSGA 211
            .| .|.|....|..|.  .||..||| ....:|.|:.:.|.|... .|....||:..:   .:..
Mouse    86 SGYRWLRDRAGAVLHG--PGPHSDHT-HGTDLGWYMAVGTHSGKEPSTATLRSPVMRE---AAPT 144

  Fly   212 C-FQFHYFMFGSGVGSLLVSIKPVSVTIGDIFKTNHPYKFDQFVMTGSQGARWLEHTIDINKMDE 275
            | .:..|.:....|..|.:.:.....|: .:::|:.|:           |..|.|..::..::..
Mouse   145 CELRLWYHIASRDVAELRLDLTHGVETL-TLWQTSGPW-----------GPGWQELAVNTGRIQG 197

  Fly   276 DFQVIFTATDARSQYGDIAIDDVKLMAAKECARRSTFIEEPKKPIEESDITDSL---GYQMTDCS 337
            ||:|.|:||...:..|.:|:|||:.   ::|...   |.:.:.|:......:..   .:|:.|..
Mouse   198 DFKVTFSATRNATHRGAVALDDVEF---RDCGLP---IPQARCPLGHHHCQNKACVEPHQLCDGE 256

  Fly   338 GRCGQDFVRGRYINEGCRCQESCLVNGNCCLNYVKECHKDLVIAPYNELKFW 389
            ..||.            |..|..|:   |..:...:....|  .|:|:|:.|
Mouse   257 DNCGD------------RSDEDPLI---CSHHMATDFETGL--GPWNQLEGW 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sr-CIV	NP_608789.1	MAM	132..306	CDD:279023	46/176 (26%)
		MAM	132..301	CDD:99706	46/171 (27%)
		Somatomedin_B	336..376	CDD:279385	6/39 (15%)
Mamdc4	NP_001074668.2	MAM	71..227	CDD:279023	47/178 (26%)
		MAM	71..224	CDD:99706	46/175 (26%)
		LDLa	234..266	CDD:238060	6/43 (14%)
		MAM	254..427	CDD:214533	12/55 (22%)
		MAM	277..427	CDD:99706	5/17 (29%)
		LDLa	462..495	CDD:238060
		MAM	498..653	CDD:279023
		MAM	499..650	CDD:99706
		MAM	660..817	CDD:214533
		MAM	665..817	CDD:99706
		MAM	823..979	CDD:279023
		MAM	823..977	CDD:99706
		MAM	983..1148	CDD:279023
		MAM	983..1144	CDD:99706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910