DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sr-CIV and MAMDC2

DIOPT Version :9

Sequence 1:NP_608789.1 Gene:Sr-CIV / 33576 FlyBaseID:FBgn0031547 Length:406 Species:Drosophila melanogaster
Sequence 2:NP_694999.3 Gene:MAMDC2 / 256691 HGNCID:23673 Length:686 Species:Homo sapiens


Alignment Length:320 Identity:81/320 - (25%)
Similarity:127/320 - (39%) Gaps:63/320 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 CLESVHLEHGSTEIVNGSIIFHCDQGYFLQGSKVFTCDRGIPRGKKPFCAKSGCQEYEQIQNGFV 84
            ||...:..:|..::.:...::..::.:.:| .|:::.... |||             ..:|....
Human   411 CLRFHYAIYGFLKMSDTLAVYIFEENHVVQ-EKIWSVLES-PRG-------------VWMQAEIT 460

  Fly    85 LNAPMKAKII----CSD--GHGLVGNRIAYCDGEKWSTQLGSCALRRQTIDV--SCDFESEDMCG 141
            ...||..|::    |..  ..|||..       :..:.|||||:...:....  .|.|| :|.|.
Human   461 FKKPMPTKVVFMSLCKSFWDCGLVAL-------DDITIQLGSCSSSEKLPPPPGECTFE-QDECT 517

  Fly   142 WTAELSFLGTW--KRVSTVADFHSEKTGPQKDHTFQNQSIGHYVRMETESDAFG-TYHFLS-PLY 202
            :|.|.....:|  :|..|...:    |||:.|||   ..:|:|:.:|.....:| ....|| || 
Human   518 FTQEKRNRSSWHRRRGETPTSY----TGPKGDHT---TGVGYYMYIEASHMVYGQKARLLSRPL- 574

  Fly   203 PKELSLSGA-CFQFHYFMFGSGVGSLLVSIKPVSVTIGDIFKTNHPYKFDQFVMTGSQGARWLEH 266
               ..:||. |..|.|.|:|.|.|.|.|.:|          |.....:...:...|.|...||..
Human   575 ---RGVSGKHCLTFFYHMYGGGTGLLSVYLK----------KEEDSEESLLWRRRGEQSISWLRA 626

  Fly   267 TIDINKMDEDFQVIFTATDARSQYGDIAIDDVKLMAA-----KECARRSTFIEEPKKPIE 321
            .|:.: .:...|:||.|....|...||||||||..|.     ::..::|:...|....||
Human   627 LIEYS-CERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPCGEMEDTTQQSSGYSEDLNEIE 685

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sr-CIVNP_608789.1 MAM 132..306 CDD:279023 56/183 (31%)
MAM 132..301 CDD:99706 55/173 (32%)
Somatomedin_B 336..376 CDD:279385
MAMDC2NP_694999.3 MAM 26..167 CDD:279023
MAM 26..167 CDD:99706
MAM 170..327 CDD:279023
MAM 170..327 CDD:99706
MAM 342..497 CDD:279023 20/107 (19%)
MAM 342..496 CDD:99706 19/106 (18%)
MAM 509..666 CDD:279023 56/179 (31%)
MAM 509..664 CDD:99706 56/177 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..543 6/25 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 665..686 4/21 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S8224
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.860

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