DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sr-CIV and MDGA2

DIOPT Version :9

Sequence 1:	NP_608789.1	Gene:	Sr-CIV / 33576	FlyBaseID:	FBgn0031547	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_001106970.4	Gene:	MDGA2 / 161357	HGNCID:	19835	Length:	1025	Species:	Homo sapiens

Alignment Length:	191	Identity:	52/191 - (27%)
Similarity:	84/191 - (43%)	Gaps:	29/191 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 CDFESEDMCGWTAELSFLGTWKRVSTVA--DFHSEKTGPQKDHTFQNQSIGHYV-----RMETES 189
            |.||..::|.:|.:.:....|.:.||..  ..::..|||..|.:...:....|:     |:|.|.
Human   817 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEK 881

  Fly   190 DAFGTYHFLSPLY------PKELSLSGACFQFHYFMFGSGVGSLLVSIKPVSVTIGDIFKTNHPY 248
                 ...|||::      |...:.:..||.|.|.|:|..:|.|.|.::         .|.....
Human   882 -----ARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLR---------LKGQTTI 932

  Fly   249 KFDQFVMTGSQGARWLEHTIDINKMDEDFQVIFTATDARSQYGDIAIDDVKLMAAKECARR 309
            :...:..:|::|.||.|..::|..: ..||:||.........||||||||.: |..|||::
Human   933 ENPLWSSSGNKGQRWNEAHVNIYPI-TSFQLIFEGIRGPGIEGDIAIDDVSI-AEGECAKQ 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sr-CIV	NP_608789.1	MAM	132..306	CDD:279023	49/186 (26%)
		MAM	132..301	CDD:99706	48/181 (27%)
		Somatomedin_B	336..376	CDD:279385
MDGA2	NP_001106970.4	IG	117..197	CDD:214652
		Ig_3	203..288	CDD:404760
		Ig strand B	224..228	CDD:409353
		Ig strand C	237..241	CDD:409353
		Ig strand E	268..272	CDD:409353
		Ig strand F	282..287	CDD:409353
		Ig strand A	313..317	CDD:409353
		IGc2	325..386	CDD:197706
		Ig strand B	327..337	CDD:409353
		Ig strand C	343..347	CDD:409353
		Ig strand C'	349..351	CDD:409353
		Ig strand D	356..361	CDD:409353
		Ig strand E	362..368	CDD:409353
		Ig strand F	375..383	CDD:409353
		Ig	418..493	CDD:416386
		Ig strand B	424..428	CDD:409353
		Ig strand C	439..443	CDD:409353
		Ig strand E	469..473	CDD:409353
		Ig strand F	483..488	CDD:409353
		Ig strand G	497..500	CDD:409353
		Ig_3	510..587	CDD:404760
		Ig strand A	511..514	CDD:409353
		Ig strand A'	519..524	CDD:409353
		Ig strand B	530..537	CDD:409353
		Ig strand C	543..548	CDD:409353
		Ig strand C'	550..552	CDD:409353
		Ig strand D	560..563	CDD:409353
		Ig strand E	567..573	CDD:409353
		Ig strand F	580..587	CDD:409353
		MAM	817..989	CDD:395504	50/187 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9778
eggNOG	1	0.900	-	-		E1_2CMY0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810