DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sr-CIV and MAMDC4

DIOPT Version :9

Sequence 1:	NP_608789.1	Gene:	Sr-CIV / 33576	FlyBaseID:	FBgn0031547	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_996803.2	Gene:	MAMDC4 / 158056	HGNCID:	24083	Length:	1137	Species:	Homo sapiens

Alignment Length:	226	Identity:	62/226 - (27%)
Similarity:	93/226 - (41%)	Gaps:	61/226 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 LRRQTIDVSCDFESEDMCGW-TAELSFLGTWKRVSTVADFHSEKTGPQKDHTFQNQSIGHYVRME 186
            |:.|..:|||:|| .|.|.| ...||.. .|:.|        |..||..|||   ...||:|.::
Human   568 LQSQPREVSCNFE-RDTCSWYPGHLSDT-HWRWV--------ESRGPDHDHT---TGQGHFVLLD 619

  Fly   187 -TESDAFG-TYHFLS----PLYPKELSLSGACFQFHYFMFGSGVGSLLVSIKPVSVTIGDIFKTN 245
             |:..|:| :.|.||    |..|.|      |..|.|.:.|..:|:|.::::...       :..
Human   620 PTDPLAWGHSAHLLSRPQVPAAPTE------CLSFWYHLHGPQIGTLRLAMRREG-------EET 671

  Fly   246 HPYKFDQFVMTGSQGARWLEHTIDINKM---DEDFQVIFTATDARSQY-GDIAIDDVKL-----M 301
            |.:.     .:|:||.||.|....::..   ...:|::|..  .|..| |.:|:|||.:     .
Human   672 HLWS-----RSGTQGNRWHEAWATLSHQPGSHAQYQLLFEG--LRDGYHGTMALDDVAVRPGPCW 729

  Fly   302 AAKECARRSTFIEEPKKPIEESDITDSLGYQ 332
            |...|:            .|:||...|.|.|
Human   730 APNYCS------------FEDSDCGFSPGGQ 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sr-CIV	NP_608789.1	MAM	132..306	CDD:279023	51/189 (27%)
		MAM	132..301	CDD:99706	50/184 (27%)
		Somatomedin_B	336..376	CDD:279385
MAMDC4	NP_996803.2	MAM	63..219	CDD:214533
		MAM	66..219	CDD:99706
		LDLa	229..261	CDD:238060
		MAM	271..425	CDD:279023
		MAM	272..422	CDD:99706
		LDLa	457..490	CDD:238060
		MAM	577..729	CDD:279023	50/184 (27%)
		MAM	577..728	CDD:99706	50/183 (27%)
		MAM	734..890	CDD:279023	7/27 (26%)
		MAM	734..888	CDD:99706	7/27 (26%)
		MAM	889..1055	CDD:214533
		MAM	894..1055	CDD:99706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9778
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910