DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17593 and Ccdc47

DIOPT Version :9

Sequence 1:	NP_001259998.1	Gene:	CG17593 / 33573	FlyBaseID:	FBgn0031544	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_080285.2	Gene:	Ccdc47 / 67163	MGIID:	1914413	Length:	483	Species:	Mus musculus

Alignment Length:	494	Identity:	214/494 - (43%)
Similarity:	310/494 - (62%)	Gaps:	29/494 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRPVFAFLLLALICFASTKSESDFEE-DDSDDFAEFDDGNFYAEPAAKNADSFSGGAGSS----- 59
            |:..:||.::.|: |.|. ||:.|:: :|.:|..|:||.:|     |:..|........|
Mouse     1 MKAFYAFCVVLLV-FGSV-SEAKFDDFEDEEDIVEYDDNDF-----AEFEDVMEDSVTESPQRVI 58

  Fly    60 HGESRDDPPAKEPRKQAQNQESDEEDGLVEDDDEFEHFQDEEEFEGYDGGDSKDPPIDQKVEPKL 124
            ..|..:|....|...|.::||.|.||...::.|......|:||||||:  |..|...::..:| :
Mouse    59 STEDDEDEATVELEGQDESQEGDFEDADTQEGDTESEPYDDEEFEGYE--DKPDTSSNKNKDP-I 120

  Fly   125 NIPNIPLHFRTHWDSYWMEMLMVAGLLAYFANFFAGKAKNARLAQLWFSTHRALLDENFALVGDD 189
            .|.::|.|.:..|:||::|:|||.|||||..|:..||.||:||||.||::||.||:.||.|||||
Mouse   121 TIVDVPAHLQNSWESYYLEILMVTGLLAYIMNYIIGKNKNSRLAQAWFNSHRELLESNFTLVGDD 185

  Fly   190 G--KAENENPGLIKESESLYTLWCSGRTCCEGMLVELKMIKRQDLVSLVAGLMRPQLDQAHIKIE 252
            |  |.......|.:|:|.:|.||||||.||||||::|:.:|||||::::|.:|||..||..||:.
Mouse   186 GTNKEATSTGKLNQENEHIYNLWCSGRVCCEGMLIQLRFLKRQDLLNVLARMMRPVSDQVQIKVT 250

  Fly   253 LTRGVMDAFVFAVGTKKTITKLFKEYTDLSKFCSLVGKPEDRYNVPTGFGVLSEIPEATSAILES 317
            :....||.:||||||:|.:.:|.||..|||:|||...|...:|.:|....:|||:.|.|..::::
Mouse   251 MNDEDMDTYVFAVGTRKALLRLQKEMQDLSEFCSDKPKSGAKYGLPDSLAILSEMGEVTEGMMDT 315

  Fly   318 RIITALNKYQSYIDYLHISDQFSGP-IQQEEGGTLKQPETKAVLLAGFNLPKHA-----EMETIK 376
            :::..|..|...|:.:|.||||||| |.||||..||.|:||..||..||:|...     :||::.
Mouse   316 KMVHFLTHYADKIESVHFSDQFSGPKIMQEEGQPLKLPDTKRTLLFTFNVPGSGNTYPKDMESLL 380

  Fly   377 PLLLLIFYLMERLKTYRMSKEGKAKSDKNRQRVEEEFLKSTHAARAEAAAQRREDKRKQEKERIL 441
            ||:.::.|.:::.|.:|:::|||.|:||||.||||.|||.||..|.|||..|||:|::.|||||:
Mouse   381 PLMNMVIYSIDKAKKFRLNREGKQKADKNRARVEENFLKLTHVQRQEAAQSRREEKKRAEKERIM 445

  Fly   442 ADEDPEKQRRWE----AKEQKRQAKRNAPKMKRLAVKSL 476
            .:||||||||.|    .:|||:..|:.. |||::.||::
Mouse   446 NEEDPEKQRRLEEAALRREQKKLEKKQM-KMKQIKVKAM 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17593	NP_001259998.1	DUF1682	138..463	CDD:285221	166/336 (49%)
Ccdc47	NP_080285.2	PRK05901	<18..>115	CDD:235640	31/103 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..119		20/74 (27%)
		DUF1682	135..467	CDD:400343	165/331 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..483		31/59 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849706
Domainoid	1	1.000	331	1.000	Domainoid score	I1152
eggNOG	1	0.900	-	-		E1_KOG2357
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41351
Inparanoid	1	1.050	388	1.000	Inparanoid score	I1997
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54689
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005627
OrthoInspector	1	1.000	-	-		oto94031
orthoMCL	1	0.900	-	-		OOG6_103006
Panther	1	1.100	-	-	LDO	PTHR12883
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5593
SonicParanoid	1	1.000	-	-		X5273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790