DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17593 and CCDC47

DIOPT Version :9

Sequence 1:	NP_001259998.1	Gene:	CG17593 / 33573	FlyBaseID:	FBgn0031544	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_064583.2	Gene:	CCDC47 / 57003	HGNCID:	24856	Length:	483	Species:	Homo sapiens

Alignment Length:	490	Identity:	214/490 - (43%)
Similarity:	303/490 - (61%)	Gaps:	28/490 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FAFLLLALICFASTKSESDFEE-DDSDDFAEFDDGNFYAEPAAKNADSFSGGAGSSH-----GES 63
            |....:.|:.|.|. ||:.|:: :|.:|..|:||.:|     |:..|........|.     .|.
Human     4 FHTFCVVLLVFGSV-SEAKFDDFEDEEDIVEYDDNDF-----AEFEDVMEDSVTESPQRVIITED 62

  Fly    64 RDDPPAKEPRKQAQNQESDEEDGLVEDDDEFEHFQDEEEFEGYDGGDSKDPPIDQKVEPKLNIPN 128
            .:|....|...|.:|||.|.||...::.|......|:||||||:  |..|....:..:| :.|.:
Human    63 DEDETTVELEGQDENQEGDFEDADTQEGDTESEPYDDEEFEGYE--DKPDTSSSKNKDP-ITIVD 124

  Fly   129 IPLHFRTHWDSYWMEMLMVAGLLAYFANFFAGKAKNARLAQLWFSTHRALLDENFALVGDDG--K 191
            :|.|.:..|:||::|:|||.|||||..|:..||.||:||||.||:|||.||:.||.||||||  |
Human   125 VPAHLQNSWESYYLEILMVTGLLAYIMNYIIGKNKNSRLAQAWFNTHRELLESNFTLVGDDGTNK 189

  Fly   192 AENENPGLIKESESLYTLWCSGRTCCEGMLVELKMIKRQDLVSLVAGLMRPQLDQAHIKIELTRG 256
            .......|.:|:|.:|.||||||.||||||::|:.:|||||::::|.:|||..||..||:.:...
Human   190 EATSTGKLNQENEHIYNLWCSGRVCCEGMLIQLRFLKRQDLLNVLARMMRPVSDQVQIKVTMNDE 254

  Fly   257 VMDAFVFAVGTKKTITKLFKEYTDLSKFCSLVGKPEDRYNVPTGFGVLSEIPEATSAILESRIIT 321
            .||.:||||||:|.:.:|.||..|||:|||...|...:|.:|....:|||:.|.|..:::::::.
Human   255 DMDTYVFAVGTRKALVRLQKEMQDLSEFCSDKPKSGAKYGLPDSLAILSEMGEVTDGMMDTKMVH 319

  Fly   322 ALNKYQSYIDYLHISDQFSGP-IQQEEGGTLKQPETKAVLLAGFNLPKHA-----EMETIKPLLL 380
            .|..|...|:.:|.||||||| |.||||..||.|:||..||..||:|...     :||.:.||:.
Human   320 FLTHYADKIESVHFSDQFSGPKIMQEEGQPLKLPDTKRTLLFTFNVPGSGNTYPKDMEALLPLMN 384

  Fly   381 LIFYLMERLKTYRMSKEGKAKSDKNRQRVEEEFLKSTHAARAEAAAQRREDKRKQEKERILADED 445
            ::.|.:::.|.:|:::|||.|:||||.||||.|||.||..|.|||..|||:|::.|||||:.:||
Human   385 MVIYSIDKAKKFRLNREGKQKADKNRARVEENFLKLTHVQRQEAAQSRREEKKRAEKERIMNEED 449

  Fly   446 PEKQRRWE----AKEQKRQAKRNAPKMKRLAVKSL 476
            ||||||.|    .:|||:..|:.. |||::.||::
Human   450 PEKQRRLEEAALRREQKKLEKKQM-KMKQIKVKAM 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17593	NP_001259998.1	DUF1682	138..463	CDD:285221	167/336 (50%)
CCDC47	NP_064583.2	Nop14	<14..>126	CDD:367841	36/120 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..118		21/73 (29%)
		DUF1682	135..467	CDD:369610	166/331 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..483		31/59 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159339
Domainoid	1	1.000	332	1.000	Domainoid score	I1143
eggNOG	1	0.900	-	-		E1_KOG2357
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41351
Inparanoid	1	1.050	388	1.000	Inparanoid score	I2028
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54689
OrthoDB	1	1.010	-	-		D1337297at2759
OrthoFinder	1	1.000	-	-		FOG0005627
OrthoInspector	1	1.000	-	-		oto90447
orthoMCL	1	0.900	-	-		OOG6_103006
Panther	1	1.100	-	-	LDO	PTHR12883
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5593
SonicParanoid	1	1.000	-	-		X5273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800