DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17593 and ccdc47

DIOPT Version :9

Sequence 1:	NP_001259998.1	Gene:	CG17593 / 33573	FlyBaseID:	FBgn0031544	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001004551.1	Gene:	ccdc47 / 447812	ZFINID:	ZDB-GENE-040912-15	Length:	486	Species:	Danio rerio

Alignment Length:	506	Identity:	209/506 - (41%)
Similarity:	306/506 - (60%)	Gaps:	57/506 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VFAFL--LLALICFASTKSESDFEEDDSDDFAEFDDGNF-----YAEPAAKNADSFSGGAGSSHG 61
            ||..|  ||.|:....|:...:.:.||.:|.|||||.:|     .:|..|.:.:
Zfish     5 VFLLLPALLLLLALPDTRGRYNDDFDDGEDIAEFDDNDFAEFEDVSEDPAVDVE----------- 58

  Fly    62 ESRDDPPAKEPRKQAQNQESDEEDGLVEDDDEFEHFQ-------------DEEEFEGYDGGDS-- 111
              ::.||  .|...:...|.||::..||::|..:.|:             |.:|||||:..:.
Zfish    59 --KEPPP--RPAPSSTPVEDDEDEATVENEDGQDEFEDTDAQDQDMYNKYDTDEFEGYEKSNPSF 119

  Fly   112 KDPPIDQKVEPKLNIPNIPLHFRTHWDSYWMEMLMVAGLLAYFANFFAGKAKNARLAQLWFSTHR 176
            ||..|.::|         |.|.:..|:||:||:|||.|||||..|:..||.||:||||.||::||
Zfish   120 KDTLIYREV---------PAHLQNSWESYYMEILMVTGLLAYIMNYIIGKNKNSRLAQAWFNSHR 175

  Fly   177 ALLDENFALVGDDG--KAENENPGLIKESESLYTLWCSGRTCCEGMLVELKMIKRQDLVSLVAGL 239
            .||:.|||||||||  |.......|.:|:|.:|.||||||.||||||::||.:|||||::::|.:
Zfish   176 ELLESNFALVGDDGTSKEATSTGKLNQENEHIYNLWCSGRVCCEGMLIQLKFLKRQDLLNVLARM 240

  Fly   240 MRPQLDQAHIKIELTRGVMDAFVFAVGTKKTITKLFKEYTDLSKFCSLVGKPEDRYNVPTGFGVL 304
            |||..||..:::.|....||.||||||::|.:.::.||..|||:||....|...:|.:|....:|
Zfish   241 MRPTCDQVQVRVTLNDEDMDTFVFAVGSRKAMARMQKEMQDLSEFCGDKPKSGAKYGIPDSLTIL 305

  Fly   305 SEIPEATSAILESRIITALNKYQSYIDYLHISDQFSGP-IQQEEGGTLKQPETKAVLLAGFNLP- 367
            ||:.|.|..:::::::..|..:...|:.:|.||||||| :.||||..||.||||..||..||:|
Zfish   306 SEMGEVTDGVMDNKMVHYLTSHADKIESIHFSDQFSGPKVMQEEGQPLKLPETKKTLLFTFNVPG 370

  Fly   368 ----KHAEMETIKPLLLLIFYLMERLKTYRMSKEGKAKSDKNRQRVEEEFLKSTHAARAEAAAQR 428
                ...:|:::.||:.::.|.::::|..|:::|||.|:|:||.||||.|||.|||.|.|||..|
Zfish   371 MGNTSPKDMDSLLPLMNMVIYSIDKVKKLRLNREGKQKADRNRARVEENFLKQTHAQRQEAAQTR 435

  Fly   429 REDKRKQEKERILADEDPEKQRRWEAKEQKRQAK---RNAPKMKRLAVKSL 476
            ||:|::.|||||:.:||||:|||.|...|:|:.|   :...|||::.||::
Zfish   436 REEKKRAEKERIMNEEDPERQRRLEEAAQRREQKKMEKKQMKMKQIKVKAM 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17593	NP_001259998.1	DUF1682	138..463	CDD:285221	163/335 (49%)
ccdc47	NP_001004551.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..99		12/66 (18%)
		DUF1682	137..466	CDD:285221	161/328 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..486		33/63 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595490
Domainoid	1	1.000	333	1.000	Domainoid score	I1112
eggNOG	1	0.900	-	-		E1_KOG2357
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41351
Inparanoid	1	1.050	379	1.000	Inparanoid score	I2032
OMA	1	1.010	-	-		QHG54689
OrthoDB	1	1.010	-	-		D1337297at2759
OrthoFinder	1	1.000	-	-		FOG0005627
OrthoInspector	1	1.000	-	-		oto38878
orthoMCL	1	0.900	-	-		OOG6_103006
Panther	1	1.100	-	-	LDO	PTHR12883
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5593
SonicParanoid	1	1.000	-	-		X5273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800