DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31954 and PRSS1

DIOPT Version :9

Sequence 1:	NP_722915.1	Gene:	CG31954 / 33572	FlyBaseID:	FBgn0051954	Length:	277	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	229	Identity:	89/229 - (38%)
Similarity:	134/229 - (58%)	Gaps:	13/229 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DGRIVGGHRINITDAPHQVSLQTSSHICGGSIISEEWILTAAHCTYGKTADRLKVRLGTSE---F 109
            |.:||||:.......|:||||.:..|.||||:|:|:|:::|.||    ...|::||||...   .
Human   246 DDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHC----YKSRIQVRLGEHNIEVL 306

  Fly   110 ARSGQLLRVQKIVQHAQFNYTNVDYDFSLLQLAHPIKFDETKKAVKLPESQMKYMDGEACFVSGW 174
            ..:.|.:...||::|.|::...::.|..|::|:.....:.....:.||.:..  ..|..|.:|||
Human   307 EGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPP--ATGTKCLISGW 369

  Fly   175 GNTQNL-LESREWLRQVEVPLVNQELCSEKYKQYGGVTERMICAGFLEGGKDACQGDSGGPMVSE 238
            |||.:. .:..:.|:.::.|:::|..|...|.  |.:|..|.|.||||||||:||||||||:|.
Human   370 GNTASSGADYPDELQCLDAPVLSQAKCEASYP--GKITSNMFCVGFLEGGKDSCQGDSGGPVVC- 431

  Fly   239 SGELVGVVSWGYGCAKPDYPGVYSRVSFARDWIK 272
            :|:|.||||||.|||:.:.||||::|.....|||
Human   432 NGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31954	NP_722915.1	Tryp_SPc	50..271	CDD:214473	85/224 (38%)
CG31954	NP_722915.1	Tryp_SPc	51..274	CDD:238113	88/226 (39%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	85/224 (38%)
		Tryp_SPc	249..467	CDD:238113	88/226 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBP0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	192	1.000	Inparanoid score	I3865
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469244at33208
OrthoFinder	1	1.000	-	-		FOG0000102
OrthoInspector	1	1.000	-	-		mtm8511
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.770