DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31954 and PRSS53

DIOPT Version :9

Sequence 1:	NP_722915.1	Gene:	CG31954 / 33572	FlyBaseID:	FBgn0051954	Length:	277	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	329	Identity:	79/329 - (24%)
Similarity:	140/329 - (42%)	Gaps:	90/329 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLVLAGVCLIPQPVK-RQRSLEDVIKNPWKLSPRLDGRIVGGHRINITDAPHQVSL-QTSSHICG 76
            :|::||..::.:.:: .||:...  :.|....|: :|..|.|      :.|.|.|: :..:|||.
Human     8 VLLIAGATVLMEGLQAAQRACGQ--RGPGPPKPQ-EGNTVPG------EWPWQASVRRQGAHICS 63

  Fly    77 GSIISEEWILTAAHCTYGKTADRL---KVRLGTSEFARSG-----QLLRVQKIVQHAQFNYTNVD 133
            ||::::.|:||||||.....|..|   .|.||:.:  |.|     :.:.|..:.....:|:.:..
Human    64 GSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQ--REGLSPGAEEVGVAALQLPRAYNHYSQG 126

  Fly   134 YDFSLLQLAHPIKFDETKKAVKLPESQMKYMDGEACFVSGWGNTQNLLESREW------------ 186
            .|.:|||||||    .|...:.||:...::..|.:|:.:||  .|:..:.:.|
Human   127 SDLALLQLAHP----TTHTPLCLPQPAHRFPFGASCWATGW--DQDTSDGKCWPRLKLGEALCLP 185

  Fly   187 -----------------------------------LRQVEVPLVNQELCSEKYKQYGGVTER--- 213
                                               ||.:.:.|:::..|:..|.|   :.:|
Human   186 SVTVSAPNCPGFQSPLLPRSQTLAPAPSLSPAPGTLRNLRLRLISRPTCNCIYNQ---LHQRHLS 247

  Fly   214 ------MICAGFLEGGKDACQGDSGGPM--VSESGELV--GVVSWGYGCAKPDYPGVYSRVSFAR 268
                  |:|.|...|.:..||||||||:  :...|..|  |::|:...||:.|.|.:.:..:...
Human   248 NPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFASSCAQEDAPVLLTNTAAHS 312

  Fly   269 DWIK 272
            .|::
Human   313 SWLQ 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31954	NP_722915.1	Tryp_SPc	50..271	CDD:214473	70/289 (24%)
CG31954	NP_722915.1	Tryp_SPc	51..274	CDD:238113	71/291 (24%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	71/290 (24%)
		Tryp_SPc	43..314	CDD:214473	70/287 (24%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149424
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940