DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31954 and KLK11

DIOPT Version :9

Sequence 1:	NP_722915.1	Gene:	CG31954 / 33572	FlyBaseID:	FBgn0051954	Length:	277	Species:	Drosophila melanogaster
Sequence 2:	XP_011524671.1	Gene:	KLK11 / 11012	HGNCID:	6359	Length:	307	Species:	Homo sapiens

Alignment Length:	282	Identity:	85/282 - (30%)
Similarity:	129/282 - (45%)	Gaps:	42/282 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PVKRQRSLEDVIKNPWKLSPRLDG---RIVGGHRINITDAPHQVSL-QTSSHICGGSIISEEWIL 86
            |::..|.|:.::   ..|:..|.|   ||:.|........|.|.:| :.:..:||.::|:..|:|
Human    29 PLQAMRILQLIL---LALATGLVGGETRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLL 90

  Fly    87 TAAHCTYGKTA---------------------DRLKVRLGTSEFARS---GQLLRVQKIVQHAQF 127
            |||||.....:                     .|..|.||.....:.   .|.....:...|..|
Human    91 TAAHCLKPWVSLTSPTHVSPDLSSSNYCLSHLSRYIVHLGQHNLQKEEGCEQTRTATESFPHPGF 155

  Fly   128 NYT--NVDY--DFSLLQLAHPIKFDETKKAVKLPESQMKYMDGEACFVSGWGNTQN-LLESREWL 187
            |.:  |.|:  |..|:::|.|:......:.:.|  |......|.:|.:||||:|.: .|.....|
Human   156 NNSLPNKDHRNDIMLVKMASPVSITWAVRPLTL--SSRCVTAGTSCLISGWGSTSSPQLRLPHTL 218

  Fly   188 RQVEVPLVNQELCSEKYKQYGGVTERMICAGFLEGGKDACQGDSGGPMVSESGELVGVVSWGYG- 251
            |...:.::..:.|...|.  |.:|:.|:||...|||||:||||||||:|... .|.|::|||..
Human   219 RCANITIIEHQKCENAYP--GNITDTMVCASVQEGGKDSCQGDSGGPLVCNQ-SLQGIISWGQDP 280

  Fly   252 CAKPDYPGVYSRVSFARDWIKE 273
            ||....||||::|....|||:|
Human   281 CAITRKPGVYTKVCKYVDWIQE 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31954	NP_722915.1	Tryp_SPc	50..271	CDD:214473	76/251 (30%)
CG31954	NP_722915.1	Tryp_SPc	51..274	CDD:238113	78/254 (31%)
KLK11	XP_011524671.1	Tryp_SPc	53..300	CDD:214473	76/251 (30%)
KLK11	XP_011524671.1	Tryp_SPc	54..303	CDD:238113	78/254 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469244at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8511
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920