DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tim and TIMELESS

DIOPT Version :9

Sequence 1:NP_001334730.1 Gene:tim / 33571 FlyBaseID:FBgn0014396 Length:1421 Species:Drosophila melanogaster
Sequence 2:NP_003911.2 Gene:TIMELESS / 8914 HGNCID:11813 Length:1208 Species:Homo sapiens


Alignment Length:1531 Identity:271/1531 - (17%)
Similarity:471/1531 - (30%) Gaps:677/1531 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 MDWLLATPQLYSAFSSLGCLEGDTYVVNPNALAILEEINYKLTYEDQTLRTFRRAIGFGQNVRSD 88
            ||..:...:|.:..|:||.||||||...|:.|..::::...|.:||:| |..|:.:|..|.::||
Human     1 MDLHMMNCELLATCSALGYLEGDTYHKEPDCLESVKDLIRYLRHEDET-RDVRQQLGAAQILQSD 64

  Fly    89 LIPLL-ENAKDDAVLESVIRILVNLTVPVECLFSVDVMYRTDVGRHTIFELNKLLYTSKEAFTEA 152
            |:|:| ::.:|..:.::|||::||||.|  .|.....:.:....||...::...|...||||...
Human    65 LLPILTQHHQDKPLFDAVIRLMVNLTQP--ALLCFGNLPKEPSFRHHFLQVLTYLQAYKEAFASE 127

  Fly   153 RSTKSVVEYMKHIL--------ESDPKLSPHKCDQINNCLLLLRNILHIPETHAHCVMPMMQSMP 209
            ::...:.|.:..:|        |.|..|       |...|||:|||||:|..     :...:.:.
Human   128 KAFGVLSETLYELLQLGWEERQEEDNLL-------IERILLLVRNILHVPAD-----LDQEKKID 180

  Fly   210 HGISMQNTILWNLFIQSIDKLLLYLMTCPQRAFWGVTMVQLIALIYKDQHVSTLQKLLSLWFEAS 274
            ...|..:.:||.:.:..:|.|||:|.:......|.:.::::::|:::||:               
Human   181 DDASAHDQLLWAIHLSGLDDLLLFLASSSAEEQWSLHVLEIVSLMFRDQN--------------- 230

  Fly   275 LSESSEDNESNTSPPKQGSGDSSPMLTSDPTSDSSDNGSNGRGMGGGMREGTAATLQEVSRKGQE 339
                          |:|.:                       |:|.|             |..||
Human   231 --------------PEQLA-----------------------GVGQG-------------RLAQE 245

  Fly   340 YQNAMARVPADKPDGSEEASDMTGNDSEQPGSPEQSQPAGESMDDGDYEDQRHRQLNEHGEEDED 404
                                                    .|.|..:.|..|.|::.|       
Human   246 ----------------------------------------RSADFAELEVLRQREMAE------- 263

  Fly   405 EDEVEEEEYLQLGPASEPLNLTQQPADKVNNTTNPTSSAPQGCLGNEPFKPPPPLPVRASTSAHA 469
                ::...||.|                                                :.|:
Human   264 ----KKTRALQRG------------------------------------------------NRHS 276

  Fly   470 QMQKFNESSYASHVSAVKLGQKSPHAGQLQLTKGKCCPQKRECPSSQSELSDCGYGTQVENQESI 534
            :.    ..||      :..|.||.....|...||                        :.|..:.
Human   277 RF----GGSY------IVQGLKSIGERDLIFHKG------------------------LHNLRNY 307

  Fly   535 STSSNDDDGPQGKPQHQKPPCNTKPRNKPRTIMSPMDKKELRRKKLVKRSKSSLINMKGLVQHTP 599
            |:    |.|.|             |:..|:       :::..|:..::| :|:|           
Human   308 SS----DLGKQ-------------PKKVPK-------RRQAARELSIQR-RSAL----------- 336

  Fly   600 TDDDISNLLKEFTVDFLLKGYSYLVEELHMQLLSNAKVPIDTSHFFWLVTYFLKF--AAQLELDM 662
               ::...|::|..:||...|:.|:..:...||.......|.:::.|.:.:|:.|  ||..... 
Human   337 ---NVRLFLRDFCSEFLENCYNRLMGSVKDHLLREKAQQHDETYYMWALAFFMAFNRAASFRPG- 397

  Fly   663 EHIDTILTYDVLSYLTY----EGVSLCEQLELNARQEGSDLKPYLRRMHLVVTAIREFLQAIDTY 723
                  |..:.||..|:    :.::...::.|..|:|.:.   :.|||||.:.|.:|.|..::..
Human   398 ------LVSETLSVRTFHFIEQNLTNYYEMMLTDRKEAAS---WARRMHLALKAYQELLATVNEM 453

  Fly   724 NKVTHLNEDD--KAHLRQLQLQISEMSDLRCLFVLLLRRFNPSIHSKQYLQDLVVTNHILLLIL- 785
            :    ::.|:  :...|.::..|..:.:.|.||:.|.|:|:.....:.:|:|||.|.|:.|.:| 
Human   454 D----ISPDEAVRESSRIIKNNIFYVMEYRELFLALFRKFDERCQPRSFLRDLVETTHLFLKMLE 514

  Fly   786 ----------------------------------------------------------------- 785
                                                                             
Human   515 RFCRSRGNLVVQNKQKKRRKKKKKVLDQAIVSGNVPSSPEEVEAVWPALAEQLQCCAQNSELSMD 579

  Fly   786 ------------------DSSAKLGGC-------------------------------------- 794
                              ::..::..|                                      
Human   580 SVVPFDAASEVPVEEQRAEAMVRIQDCLLAGQAPQALTLLRSAREVWPEGDVFGSQDISPEEEIQ 644

  Fly   795 -----------------------------------QTIRLSE-------HITQFATLEVMHYYGI 817
                                               |.:::||       ::.:||...|:..|.:
Human   645 LLKQILSAPLPRQQGPEERGAEEEEEEEEEEEEELQVVQVSEKEFNFLDYLKRFACSTVVRAYVL 709

  Fly   818 LLEDFNNNGEFVNDCIFTMMHHIGGDLGQIGVLFQPIILKTYSRI-------------------- 862
            ||..:..|....|.||..|:|.:..||....:|||..:...::|:                    
Human   710 LLRSYQQNSAHTNHCIVKMLHRLAHDLKMEALLFQLSVFCLFNRLLSDPAAGAYKELVTFAKYIL 774

  Fly   863 -------------------WE---------ADYELCDD---------WS---------------- 874
                               |:         ..|...||         ||                
Human   775 GKFFALAAVNQKAFVELLFWKNTAVVREMTEGYGSLDDRSSSRRAPTWSPEEEAHLRELYLANKD 839

  Fly   875 ----DLIEYVIHKFMNTPPKSPLTI----PTTSLTEMTKEHNQEHT-VCSWSQEEMDTLYWYYVQ 930
                |::|.:: ..:||.|::...|    ....|.:..|:..::.| :..|:.::...|...:.:
Human   840 VEGQDVVEAIL-AHLNTVPRTRKQIIHHLVQMGLADSVKDFQRKGTHIVLWTGDQELELQRLFEE 903

  Fly   931 SKKNNDIVGKIVKLFSNNGNKLKTRISIIQQLLQQDIITLLEYDDLMK----------------- 978
            .:.::|::|.|:|    |....::|..|:.:||...::.  |..:|.|                 
Human   904 FRDSDDVLGHIMK----NITAKRSRARIVDKLLALGLVA--ERRELYKKRQKKLASSILPNGAES 962

  Fly   979 -----FEDAEYQRTLLTTPTSATTESGIEIKECAYGKPSDDVQILLDLIIKENKAQH-------- 1030
                 .||.|.:..|....:....|.|.|         ::.||..| ::..||..|.        
Human   963 LKDFCQEDLEEEENLPEEDSEEEEEGGSE---------AEQVQGSL-VLSNENLGQSLHQEGFSI 1017

  Fly  1031 -LLWLQRILIECCFVKLTLRSGLKVPEGDHIMEPVAYHCICKQKSIPVVQWNNEQSTTMLYQPFV 1094
             |||||..||.....:          |.|.          |.| ::|:|....|....|..:.|.
Human  1018 PLLWLQNCLIRAADDR----------EEDG----------CSQ-AVPLVPLTEENEEAMENEQFQ 1061

  Fly  1095 LLLHKLGIQLPADAGSIFARIPDYWTPETMYGLAKKLGPLDKLNLKFDASELEDATASSPSRYHH 1159
            .||.|||::.||.....|.|||            .||.|                          
Human  1062 QLLRKLGVRPPASGQETFWRIP------------AKLSP-------------------------- 1088

  Fly  1160 TGPRNSLSSVSSLDVDLGDTEELALIPEVDAAV-------------EKAHAM----------AST 1201
            |..|.:.:|:|..:      ||..|.||:...|             .:|.|:          |..
Human  1089 TQLRRAAASLSQPE------EEQKLQPELQPKVPGEQGSDEEHCKEHRAQALRALLLAHKKKAGL 1147

  Fly  1202 PSPSEIFAVPKTKHCNSIIRYTPDPTPPVPNWLQLV 1237
            .||.|..||.|            :|....|...||:
Human  1148 ASPEEEDAVGK------------EPLKAAPKKRQLL 1171

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
timNP_001334730.1 None
TIMELESSNP_003911.2 Required for homodimerization and for interaction with CRY1 and CHEK1. /evidence=ECO:0000250|UniProtKB:Q9R1X4 1..309 98/520 (19%)
TIMELESS 25..284 CDD:282651 80/447 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..679 0/23 (0%)
TIMELESS_C 728..1200 CDD:252956 103/538 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 971..994 5/31 (16%)
Interaction with PARP1. /evidence=ECO:0000269|PubMed:26344098 1000..1098 35/156 (22%)
Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q9R1X4 1082..1208 28/146 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1091..1131 9/45 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1143..1208 11/41 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1974
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22940
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
43.960

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