DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tim and timeless

DIOPT Version :9

Sequence 1:NP_001334730.1 Gene:tim / 33571 FlyBaseID:FBgn0014396 Length:1421 Species:Drosophila melanogaster
Sequence 2:NP_001265529.1 Gene:timeless / 325855 ZFINID:ZDB-GENE-030131-8978 Length:1278 Species:Danio rerio


Alignment Length:1477 Identity:248/1477 - (16%)
Similarity:458/1477 - (31%) Gaps:616/1477 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 MDWLLATPQLYSAFSSLGCLEGDTYVVNPNALAILEEINYKLTYEDQTLRTFRRAIGFGQNVRSD 88
            ||..:...:|.:..|:||.||||.|...|:.|..::::...|.:||.. |..|:.:|.||.:::|
Zfish     1 MDLYMMNCELLATCSALGYLEGDVYHKEPDCLESVKDLIRYLRHEDDA-RDIRQQLGAGQILQND 64

  Fly    89 LIPLL-ENAKDDAVLESVIRILVNLTVPVECLFSV---DVMYRTDVGRHTIFELNKLLYTSKEAF 149
            |:|:: ::.:|..:.::.||::||||.|....|..   |..:     ||...::...|...||||
Zfish    65 LLPIITQHTQDKPLFDACIRLMVNLTQPALLCFGKIPDDPAF-----RHHFLQVTSYLQAYKEAF 124

  Fly   150 TEARSTKSVVEYMKHILESDPKLSPHKCD-QINNCLLLLRNILHIPETHAHCVMPMMQ-SMPHGI 212
            .:.:....:.|.:.::|:.|.:....:.: .|...|||:||:||:|..      |..: ::....
Zfish   125 ADEKVFTVLSETLYNLLQLDWEQRDEEDNLLIERILLLVRNVLHVPAD------PYEEKNVDDDA 183

  Fly   213 SMQNTILWNLFIQSIDKLLLYLMTCPQRAFWGVTMVQLIALIYKDQHVSTLQKLLSLWFEASLSE 277
            |:.:.:||.:.|..:|.||.:|........|...::::|:|:::||   |.:.|:|         
Zfish   184 SVHDKLLWAIHISGLDDLLKFLACAQSEQQWSFHILEIISLMFRDQ---TAELLVS--------- 236

  Fly   278 SSEDNESNTSPPKQGSGDSSPMLTSDPTSDSSDNGSNGRGMGGGMREGTAATLQEVSRKGQEYQN 342
                                                     .|.||..                 
Zfish   237 -----------------------------------------AGQMRSA----------------- 243

  Fly   343 AMARVPADKPDGSEEASDMTGNDSEQPGSPEQSQPAGESMDDGDYEDQRHRQLNEHGEEDEDEDE 407
                                                                       .|.:.:
Zfish   244 -----------------------------------------------------------QEKQKD 249

  Fly   408 VEEEEYLQLGPASEPLNLTQQPADKVNNTTNPTSSAPQGCLGNEPFKPPPPLPVRASTSAHAQMQ 472
            ::|.|.|:          .::.|:|.:.|.                                 |:
Zfish   250 MQELELLR----------QKETAEKRSRTL---------------------------------MR 271

  Fly   473 KFNESSYASHVSAVKLGQKSPHAGQLQLTKGKCCPQKRECPSSQSELSDCGYGTQVENQESISTS 537
            ....|.:..  |.|..|.||  .|:                      :|..|...:.|.:|.|..
Zfish   272 GTRHSRFRG--SYVIEGLKS--IGE----------------------NDVVYHQGLHNFKSYSHD 310

  Fly   538 SNDDDGPQGKPQHQKPPCNTKPRNKPRTIMSPMDKKELRRKKLVKRSKSSLINMKGLVQHTPTDD 602
                   .||...:.|                      :||::.|.|.|          |..:..
Zfish   311 -------LGKAVRRVP----------------------KRKQMAKDSDS----------HRRSAL 336

  Fly   603 DISNLLKEFTVDFLLKGYS---YLVEELHMQLLSNAKVPIDTSHFFWLVTYFLKFAAQLELDMEH 664
            ::...|:||.:|||...|:   |||:|   .|:.......|.:::.|.:|:|:.|..     :::
Zfish   337 NVRLFLREFCIDFLENCYNRLMYLVKE---GLIRERAQQHDETYYMWALTFFMAFNR-----LQN 393

  Fly   665 IDTILTYDVLSYLTYEGV--SLCEQLELNARQEGSDLKPYLRRMHLVVTAIREFLQAIDTYNKVT 727
            ....:..:.:|..|:..:  ::....|:....: ||...:.|||||.:.|.:|.|.   |.|::.
Zfish   394 FKPDVVSETISIRTFHFIEKNITNYYEMMLTDK-SDATSWSRRMHLALKAYQELLL---TVNEMD 454

  Fly   728 HLNEDDKAHLRQ-LQLQISEMSDLRCLFVLLLRRFNPSIHSKQYLQDLVVTNHILLLILDSSAK- 790
            ...:::..|... ::..|..:.:.|.:|:.|||:::..:..:.:|:|||.:.|:.|.:|:...| 
Zfish   455 RSKDENIRHSSSVIKSNIFYLMEFREIFLTLLRKYDERLQPRSFLRDLVESAHLFLRMLERFCKG 519

  Fly   791 ----------------------------------------------------------------- 790
                                                                             
Zfish   520 RNNLVVQKKRVKRKKRSQKKPEMETSAEDLEQSWQIVSEELRASGFQLPESLTEGAVPFDAASDT 584

  Fly   791 ------------LGGC------------------------------------------------- 794
                        :..|                                                 
Zfish   585 PVNEQRTEALVRIQDCLMSRAGPEALSLLRAARAVWPEGDTFGSVEVEPEEELELLKQILFTKLP 649

  Fly   795 -----------------------QTIRLSE-------HITQFATLEVMHYYGILLEDFNNNGEFV 829
                                   :::.:||       .|.:||...::..|.|||..::.|....
Zfish   650 RTVPLDSAVEEEDGDELVEEEELESVAVSETEFNFLDFIKRFAHPNIVRPYVILLRSYSQNSPHT 714

  Fly   830 NDCIFTMMHHIGGDLGQIGVLFQPIILKTYSRI-------------------------------- 862
            |.|:..|:|.:..||....:|:|..:...:::|                                
Zfish   715 NHCVTRMLHRLAVDLKMEALLYQLSVFSLFNKILGDPAAAAYQELVKFAKYVLNRFFVFAATNNK 779

  Fly   863 -------WE---ADYELCD-------------DWSDLIE------YVIHKFMNTPPKSPLTIPTT 898
                   |:   |..|:.:             .|:...|      |..||....|......:|..
Zfish   780 AFVELLFWKNVGAVREMTEGYTKDGEGSKKKSKWTPEEEAELQRLYEEHKDSGVPDVVETLLPLL 844

  Fly   899 S----------------LTEMTKEHNQEH---TVCSWSQEEMDTLYWYYVQSKKNNDIVGKIVKL 944
            |                |.:..|:..:|.   .:..|::|:...|...:...:.::|::|.|:|.
Zfish   845 SSSRTRREVVSHLVSMGLVDSVKDLKKEKKGTRIVLWTEEQEQELQGLFEDFQDSDDVLGNILKR 909

  Fly   945 FSNNGNKLKTRISIIQQLLQQDIITLLEYDDLMKFEDAEYQRTLLTTPTSATTESGI----EIKE 1005
            .:..    ::|..|:.::|...:::  :..:|.|    :.||......|..|.|...    |::|
Zfish   910 ITAK----RSRARIVDKILSMGLVS--DRKELYK----KRQRGAHGKSTGMTEEQFFDMTGEMQE 964

  Fly  1006 CAYGKPSDDVQILLDLIIKENKAQH---------------------------------------- 1030
            .......||.:...|...::...||                                        
Zfish   965 KDIEDEEDDDEDDDDKSDQDEDEQHYEKQQTVRSAKKHQKSTSRDISSEKIHSLRKMVQALQLEG 1029

  Fly  1031 ----LLWLQRILIECCFVKLTLRSGLKVPEGDHIMEPVAYHCICKQKSIPVVQWNNEQSTTMLYQ 1091
                :||||.          :|.......|.|.:..|||.        :|:.:.|.:   .|..:
Zfish  1030 LSGPVLWLQN----------SLNRTADDREEDGVSHPVAL--------VPLTEENED---AMENR 1073

  Fly  1092 PFVLLLHKLGIQLPADAGSIFARIPDYWTPETMYGLAKKLGPLDKLNLKFDASE-----LED--- 1148
            .|..||..:||:.|::....|.||....:...:..||..|.||::...:.|:.|     :||   
Zfish  1074 SFQKLLRAVGIRAPSEGQETFWRISSSLSVNQLRTLAASLEPLEETGAEGDSEEKDSRSVEDDEN 1138

  Fly  1149 -------------ATASSPSRYHHTG-PRNSLSSVSSLDVDLGDTEE 1181
                         |...|..|.|.:. |::|.|     ..|:.|:.|
Zfish  1139 ENDNQEMRAQALRALLLSRQRKHTSAKPKDSPS-----QEDISDSVE 1180

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
timNP_001334730.1 None
timelessNP_001265529.1 TIMELESS 25..284 CDD:282651 73/444 (16%)
TIMELESS_C 721..1275 CDD:252956 86/496 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170596648
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1974
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22940
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
65.890

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