Protein Alignment tim and Timeless

DIOPT Version :9

• Sequence 1: NP_001334730.1
• Gene: tim / 33571
• FlyBaseID: FBgn0014396
• Length: 1421
• Species: Drosophila melanogaster
• Sequence 2: XP_006513643.1
• Gene: Timeless / 21853
• MGIID: 1321393
• Length: 1258
• Species: Mus musculus
• Alignment Length: 1449
• Identity: 262/1449 - (18%)
• Similarity: 459/1449 - (31%)
• Gaps: 591/1449 - (40%)

  Fly    24 MDWLLATPQLYSAFSSLGCLEGDTYVVNPNALAILEEINYKLTYEDQTLRTFRRAIGFGQNVRSD 88
            ||..:...:|.:..|:||.|||.||...|:.|..::::...|.:||:| |..|:.:|..|.::||
Mouse    62 MDLYMMNCELLATCSALGYLEGGTYHKEPDCLESVKDLIRYLRHEDET-RDVRQQLGAAQILQSD 125

  Fly    89 LIPLL-ENAKDDAVLESVIRILVNLTVP-VECLFSVDVMYRTDVGRHTIFELNKLLYTSKEAFTE 151
            |:|:| ::.:|..:.::|||::||||.| :.|..||.   :....||...::...|...||||..
Mouse   126 LLPILTQHRQDKPLFDAVIRLMVNLTQPALLCFGSVP---KDSSVRHHFLQVLTYLQAYKEAFAS 187

  Fly   152 ARSTKSVVEYMKHIL--------ESDPKLSPHKCDQINNCLLLLRNILHIPETHAHCVMPMMQSM 208
            .::...:.|.:..:|        |.|..|       |...|||:|||||:|..     :...:|:
Mouse   188 EKAFGVLSETLYELLQLGWEDRQEEDNLL-------IERILLLVRNILHVPAN-----LEQEKSI 240

  Fly   209 PHGISMQNTILWNLFIQSIDKLLLYLMTCPQRAFWGVTMVQLIALIYKDQHVSTLQKLLSLWFEA 273
            ....|:.:.:||.:.:..:|.|||:|.:......|.:.::::|:|:::||
Mouse   241 DDDASIHDRLLWAIHLSGMDDLLLFLSSSSAEQQWSLHVLEIISLMFRDQ--------------- 290

  Fly   274 SLSESSEDNESNTSPPKQGSGDSSPMLTSDPTSDSSDNGSNGRGMGGGMREGTAATLQEVSRKGQ 338
                          .|:|.:                       |:|.|             |..|
Mouse   291 --------------TPEQLA-----------------------GVGQG-------------RLAQ 305

  Fly   339 EYQNAMARVPADKPDGSEEASDMTGNDSEQPGSPEQSQPAGESMDDGDYEDQRHRQLNEHGEEDE 403
            |                                        .|.|..:.|..|.|::.|
Mouse   306 E----------------------------------------RSTDVAELEVLRQREMAE------ 324

  Fly   404 DEDEVEEEEYLQLGPASEPLNLTQQPADKVNNTTNPTSSAPQGCLGNEPFKPPPPLPVRASTSAH 468
                 :....||.|                                                :.|
Mouse   325 -----KRARALQRG------------------------------------------------NRH 336

  Fly   469 AQMQKFNESSYASHVSAVK-LGQKSP--HAGQLQLTKGKCCPQKRECPSSQSELSDCGYGTQVEN 530
            ::.    ..||.  |..:| :|:|..  |.|...|               |:..||.|
Mouse   337 SRF----GGSYI--VQGLKSIGEKDVVFHKGLHNL---------------QNYSSDLG------- 373

  Fly   531 QESISTSSNDDDGPQGKPQHQKPPCNTKPRNKPRTIMSPMDKKELRRKKLVKRSKSSLINMKGLV 595
                                      .:||..|:...:..:....||         |::|::
Mouse   374 --------------------------KQPRRVPKRRQAAQELSVHRR---------SVLNVR--- 400

  Fly   596 QHTPTDDDISNLLKEFTVDFLLKGYSYLVEELHMQLLSNAKVPIDTSHFFWLVTYFLKF--AAQL 658
                      ..|::|..:||...|:.|:..:...||.......|.:::.|.:.:|:.|  ||..
Mouse   401 ----------LFLRDFCSEFLENCYNPLMGAVKDHLLRERAQQHDETYYMWAMAFFMAFNRAATF 455

  Fly   659 ELDMEHIDTILTYDVLSYLTY----EGVSLCEQLELNARQEGSDLKPYLRRMHLVVTAIREFLQA 719
            ...       |..:.||..|:    :.::...::.|..|:|.:.   :.|||||.:.|.:|.|..
Mouse   456 RPG-------LVSETLSIRTFHFVEQNLTNYYEMMLTDRKEAAS---WARRMHLALKAYQELLAT 510

  Fly   720 IDTYNKVTHLNEDDKAHLRQLQLQISEMSDLRCLFVLLLRRFNPSIHSKQYLQDLVVTNHILLLI 784
            ::..:...  :|..:...|.::..|..|.:.|.||:.|.|:|:...|.:.:|:|||.|.|:.|.:
Mouse   511 VNEMDMCP--DEAVRESSRIIKNNIFYMMEYRELFLALFRKFDERYHPRSFLRDLVETTHLFLKM 573

  Fly   785 L---------------------------------------------------------------- 785
            |
Mouse   574 LERFCRSRGNLMVQNKRKKRKKKKKVQDQGVAFSQSPGELEAMWPALAEQLLQCAQDPELSVDPV 638

  Fly   786 ----------------DSSAKLGGC---------------------------------------- 794
                            ::..::..|
Mouse   639 VPFDAASEVPVEEQRVEAMVRIQDCLTAGQAPQALALLRSAREVWPEGNAFGSPVISPGEEMQLL 703

  Fly   795 -------------------------------QTIRLS-------EHITQFATLEVMHYYGILLED 821
                                           |.:::|       |::.:||:..::..|.:||..
Mouse   704 KQILSTPLPRQQEPEEGDAEEEEEEEEEEELQVVQVSEKEFNFLEYLKRFASSTIVRAYVLLLRS 768

  Fly   822 FNNNGEFVNDCIFTMMHHIGGDLGQIGVLFQPIILKTYSRIWEADYELCDD----WSDLI---EY 879
            :..|....|.||..|:|.:...||...:|||..:...::|:      |.|.    :.:|:   :|
Mouse   769 YRQNSAHTNHCIAKMLHRLAHGLGMEALLFQLSLFCLFNRL------LSDPAAAAYKELVTFAKY 827

  Fly   880 VIHKFM-----------------------------------NTPPKSPL---------------- 893
            :|.||.                                   ::..::||
Mouse   828 IIGKFFALAAVNQKAFVELLFWKNTAVVREMTQGYGSLDSGSSSHRAPLWSPEEEAQLQELYLAH 892

  Fly   894 -----------------TIPTT-----------SLTEMTKEHNQEH--TVCSWSQEEMDTLYWYY 928
                             .:|.|           .|.:..||..:..  .:..|::::...|...:
Mouse   893 KDVEGQDVVETILAHLKVVPRTRKQVIHHLVRMGLADSVKEFQKRKGTQIVLWTEDQELELQRLF 957

  Fly   929 VQSKKNNDIVGKIVKLFSNNGNKLKTRISIIQQLLQQDIITLLEYDDLMK--------------- 978
            .:.:.::|::|:|:|    |....::|..::.:||...:::  |...|.|
Mouse   958 EEFRDSDDVLGQIMK----NITAKRSRARVVDKLLALGLVS--ERRQLYKKRRKKLAPSCMQNGE 1016

  Fly   979 -------FEDAEYQRTLLTTPTSATTES--GIEIKECAYGKPSDDVQILLDLIIKENKAQHLLWL 1034
                   .||.|.:...|....|...||  |:...: ..|..|...:.|.:.:.:|..:..||||
Mouse  1017 KSPRDPWQEDPEEEDEHLPEDESEDEESEEGLPSGQ-GQGSSSLSAENLGESLRQEGLSAPLLWL 1080

  Fly  1035 QRILIECCFVKLTLRSGLKVPEGDHIMEPVAYHCICKQKSIPVVQWNNEQSTTMLYQPFVLLLHK 1099
            |..||..        :..:..:|            |.| :||:|....|....|..:.|..||.|
Mouse  1081 QSSLIRA--------ANDREEDG------------CSQ-AIPLVPLTEENEEAMENEQFQHLLRK 1124

  Fly  1100 LGIQLPADAGSIFARIPDYWTPETMYGLAKKLGPLDKLNLKFDASELEDATASSPSRYHHTGPRN 1164
            |||:.|:.....|.|||...:...:..:|..|...:....:.:..|........||..|.|....
Mouse  1125 LGIRPPSSGQETFWRIPAKLSSTQLRRVAASLSQQENEEEREEEPEPGVPGEQGPSEEHRTEALR 1189

  Fly  1165 SLSSVSSLDVDLGDTEELA 1183
            :|.|.......||.|||.|
Mouse  1190 ALLSARKRKAGLGPTEEEA 1208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tim	NP_001334730.1	None
Timeless	XP_006513643.1	TIMELESS	86..345	CDD:368140	84/444 (19%)
		TIMELESS_C	783..1251	CDD:252956	89/460 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850662
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1974
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22940
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.890